John Guy may refer to:

• John Guy (New Zealand cricketer) (born 1934), played 12 Test matches for New Zealand 1955–61
• John Guy (English cricketer) (1916–1997), English cricketer who played first-class cricket for Oxford University, Kent and Warwickshire
• John Guy (colonial administrator) (1568–1629), coloniser of Newfoundland
• John Guy (historian) (born 1949), British historian of Tudor England
• John J. Guy (born 1950), British educationalist
• John Hudson Guy, Chief Justice of Jamaica in 1749

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