From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
GCKR |
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Available structures |
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PDB | Ortholog search:
PDBe
RCSB |
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List of PDB id codes |
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4PXS,
4BBA,
4MQU,
4OLH,
4MSU,
4BB9,
4OHP,
4OP1,
4OP3,
4OHM,
4OHO,
4MRO,
4PX2,
4PX3,
4PX5,
4OHK,
4LY9,
4OP2 |
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Identifiers |
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Aliases |
GCKR, FGQTL5, GKRP, glucokinase (hexokinase 4) regulator, glucokinase regulator |
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External IDs |
OMIM:
600842;
MGI:
1096345;
HomoloGene:
1139;
GeneCards:
GCKR;
OMA:
GCKR - orthologs |
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Wikidata |
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Glucokinase regulator is a
protein that in
humans is encoded by the
GCKR
gene.
[5]
Function
This
gene encodes a protein belonging to the GCKR subfamily of the SIS (
sugar
isomerase) family of proteins. The gene product is a
regulatory protein that inhibits
glucokinase in
liver and
pancreatic islet
cells by binding
non-covalently to form an inactive complex with the
enzyme. This gene is considered a susceptibility gene candidate for a form of
maturity onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008].
References
Further reading
- Veiga-da-Cunha M, Delplanque J, Gillain A, Bonthron DT, Boutin P, Van Schaftingen E, Froguel P (May 2003).
"Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians". Diabetologia. 46 (5): 704–11.
doi:
10.1007/s00125-003-1083-y.
PMID
12739015.
- Veiga-da-Cunha M, Delplanque J, Gillain A, Bonthron DT, Boutin P, Van Schaftingen E, Froguel P (May 2003).
"Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians". Diabetologia. 46 (5): 704–11.
doi:
10.1007/s00125-003-1083-y.
PMID
12739015.
- Brocklehurst KJ, Davies RA, Agius L (March 2004).
"Differences in regulatory properties between human and rat glucokinase regulatory protein". Biochem. J. 378 (Pt 2): 693–7.
doi:
10.1042/BJ20031414.
PMC
1223974.
PMID
14627435.
- Køster B, Fenger M, Poulsen P, Vaag A, Bentzen J (December 2005).
"Novel polymorphisms in the GCKR gene and their influence on glucose and insulin levels in a Danish twin population". Diabet. Med. 22 (12): 1677–82.
doi:
10.1111/j.1464-5491.2005.01700.x.
PMID
16401311.
S2CID
20786263.
- Heredia VV, Carlson TJ, Garcia E, Sun S (December 2006).
"Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations". J. Biol. Chem. 281 (52): 40201–7.
doi:
10.1074/jbc.M607987200.
PMID
17082186.
- García-Herrero CM, Galán M, Vincent O, Flández B, Gargallo M, Delgado-Alvarez E, Blázquez E, Navas MA (February 2007).
"Functional analysis of human glucokinase gene mutations causing MODY2: exploring the regulatory mechanisms of glucokinase activity". Diabetologia. 50 (2): 325–33.
doi:
10.1007/s00125-006-0542-7.
PMID
17186219.
- Ellard S, Thomas K, Edghill EL, Owens M, Ambye L, Cropper J, Little J, Strachan M, Stride A, Ersoy B, Eiberg H, Pedersen O, Shepherd MH, Hansen T, Harries LW, Hattersley AT (November 2007).
"Partial and whole gene deletion mutations of the GCK and HNF1A genes in maturity-onset diabetes of the young". Diabetologia. 50 (11): 2313–7.
doi:
10.1007/s00125-007-0798-6.
PMID
17828387.
- Sparsø T, Andersen G, Nielsen T, Burgdorf KS, Gjesing AP, Nielsen AL, Albrechtsen A, Rasmussen SS, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Madsbad S, Hansen T, Pedersen O (January 2008).
"The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes". Diabetologia. 51 (1): 70–5.
doi:
10.1007/s00125-007-0865-z.
PMID
18008060.
- Sparsø T, Andersen G, Nielsen T, Burgdorf KS, Gjesing AP, Nielsen AL, Albrechtsen A, Rasmussen SS, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Madsbad S, Hansen T, Pedersen O (January 2008).
"The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes". Diabetologia. 51 (1): 70–5.
doi:
10.1007/s00125-007-0865-z.
PMID
18008060.
This article incorporates text from the
United States National Library of Medicine, which is in the
public domain.