Giant condyloma acuminatum | |
---|---|
Other names | Giant condyloma of Buschke–Löwenstein tumor |
Man, aged 63, with a massive cauliflower-like penile mass with several urinary fistulae making the penile shaft indistinguishable. | |
Specialty | Infectious diseases |
Giant condyloma acuminatum (also known as a Buschke–Löwenstein tumor [1]) is a rare cutaneous condition characterized by an aggressive, wart-like growth that is a verrucous carcinoma. [2]: 409 It is attributed to human papillomavirus. [3]
Due to their size, these tumors can be locally invasive and destructive. Owing to their impressive growth patterns, Buschke-Löwenstein tumors displace and destroy adjacent structures from compression. [4] In general these masses are benign, but the potential for malignant transformation to squamous cell carcinoma exists in the long term, as does the rare risk for metastasis. [5] [6] [7] [8] Buschke-Löwensteoin tumors are frequently associated with HPV subtypes 6 and 11. [4]
Treatment involves surgical resection and possible chemoradiotherapy. [6] [8] [7] Although penile sparing is the goal, total penectomy may be required. They have high recurrence rates; therefore, close follow-up is crucial. [4]
Giant condyloma acuminatum | |
---|---|
Other names | Giant condyloma of Buschke–Löwenstein tumor |
Man, aged 63, with a massive cauliflower-like penile mass with several urinary fistulae making the penile shaft indistinguishable. | |
Specialty | Infectious diseases |
Giant condyloma acuminatum (also known as a Buschke–Löwenstein tumor [1]) is a rare cutaneous condition characterized by an aggressive, wart-like growth that is a verrucous carcinoma. [2]: 409 It is attributed to human papillomavirus. [3]
Due to their size, these tumors can be locally invasive and destructive. Owing to their impressive growth patterns, Buschke-Löwenstein tumors displace and destroy adjacent structures from compression. [4] In general these masses are benign, but the potential for malignant transformation to squamous cell carcinoma exists in the long term, as does the rare risk for metastasis. [5] [6] [7] [8] Buschke-Löwensteoin tumors are frequently associated with HPV subtypes 6 and 11. [4]
Treatment involves surgical resection and possible chemoradiotherapy. [6] [8] [7] Although penile sparing is the goal, total penectomy may be required. They have high recurrence rates; therefore, close follow-up is crucial. [4]