Neuroscientist and psychiatrist exploring effects of cannabis use
Gabriella Gobbi is an Italo-Canadian psychiatrist and neuroscientist whose research explores novel treatments for mental health disorders.[1][2][3] Gobbi is a professor at
McGill University's Department of Psychiatry and a
Canada Research Chair (Tier 1) in Therapeutics for Mental Health.[2][4]
Cannabis and association with depression in adolescence
Dr. Gobbi's lab discovered that adolescent cannabis consumption induces depression-like behavior in animals.[9][10] Upon finding that there is a link between
depression and long-term
cannabis consumption in young people,[11] Gobbi engaged widely with stakeholders and the media, ultimately resulting in a change in the legal age of cannabis consumption in
Quebec from 18 to 21, and her receiving the 2020 Principal's Prize for Public Engagement through Media (Established Academics category) from McGill University.[12]
Melatonin MT2 receptor agonists for pain and insomnia
Even if
melatonin was isolated more than 60 years ago, the roles of
GPCRmelatonin receptors (named MT1 and MT2) remained unknown. Her lab discovered that the MT1 and MT2 receptors have very specialized functions: while the MT1 activates
REM sleep, the MT2 receptor acts on
NREM sleep.[13][14] Her lab also synthesized and developed novel selective MT2 receptors
partial agonists for the treatment of
insomnia[15] and
neuropathic pain.[16]
Gobbi, G., Bambico, F. R., Mangieri, R., Bortolato, M., Campolongo, P., Solinas, M., ... & Piomelli, D. (2005). Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proceedings of the National Academy of Sciences, 102(51), 18620-18625.
Gobbi, G., Atkin, T., Zytynski, T., Wang, S., Askari, S., Boruff, J., ... & Mayo, N. (2019). Association of cannabis use in adolescence and risk of depression, anxiety, and suicidality in young adulthood: a systematic review and meta-analysis. JAMA psychiatry, 76(4), 426-434.
Comai, S., & Gobbi, G. (2014). CCNP Award Paper: Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology. Journal of Psychiatry and Neuroscience, 39(1), 6-21.
Posa, Luca, Danilo De Gregorio, Gabriella Gobbi, and Stefano Comai. "Targeting melatonin MT2 receptors: a novel pharmacological avenue for inflammatory and neuropathic pain." Current medicinal chemistry 25, no. 32 (2018): 3866-3882.
Lopez-Canul, M., Palazzo, E., Dominguez-Lopez, S., Luongo, L., Lacoste, B., Comai, S., ... & Gobbi, G. (2015). Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways. Pain, 156(2), 305-317.
De Gregorio, D., Popic, J., Enns, J. P., Inserra, A., Skalecka, A., Markopoulos, A., ... & Gobbi, G. (2021). Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission. Proceedings of the National Academy of Sciences, 118(5), e2020705118.
De Gregorio, D., Inserra, A., Enns, J. P., Markopoulos, A., Pileggi, M., El Rahimy, Y., ... & Gobbi, G. (2022). Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline. Neuropsychopharmacology, 47(6), 1188-1198.
Aguilar-Valles, A., De Gregorio, D., Matta-Camacho, E., Eslamizade, M. J., Khlaifia, A., Skaleka, A., ... & Sonenberg, N. (2021). Antidepressant actions of ketamine engage cell-specific translation via eIF4E. Nature, 590(7845), 315-319.
Neuroscientist and psychiatrist exploring effects of cannabis use
Gabriella Gobbi is an Italo-Canadian psychiatrist and neuroscientist whose research explores novel treatments for mental health disorders.[1][2][3] Gobbi is a professor at
McGill University's Department of Psychiatry and a
Canada Research Chair (Tier 1) in Therapeutics for Mental Health.[2][4]
Cannabis and association with depression in adolescence
Dr. Gobbi's lab discovered that adolescent cannabis consumption induces depression-like behavior in animals.[9][10] Upon finding that there is a link between
depression and long-term
cannabis consumption in young people,[11] Gobbi engaged widely with stakeholders and the media, ultimately resulting in a change in the legal age of cannabis consumption in
Quebec from 18 to 21, and her receiving the 2020 Principal's Prize for Public Engagement through Media (Established Academics category) from McGill University.[12]
Melatonin MT2 receptor agonists for pain and insomnia
Even if
melatonin was isolated more than 60 years ago, the roles of
GPCRmelatonin receptors (named MT1 and MT2) remained unknown. Her lab discovered that the MT1 and MT2 receptors have very specialized functions: while the MT1 activates
REM sleep, the MT2 receptor acts on
NREM sleep.[13][14] Her lab also synthesized and developed novel selective MT2 receptors
partial agonists for the treatment of
insomnia[15] and
neuropathic pain.[16]
Gobbi, G., Bambico, F. R., Mangieri, R., Bortolato, M., Campolongo, P., Solinas, M., ... & Piomelli, D. (2005). Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proceedings of the National Academy of Sciences, 102(51), 18620-18625.
Gobbi, G., Atkin, T., Zytynski, T., Wang, S., Askari, S., Boruff, J., ... & Mayo, N. (2019). Association of cannabis use in adolescence and risk of depression, anxiety, and suicidality in young adulthood: a systematic review and meta-analysis. JAMA psychiatry, 76(4), 426-434.
Comai, S., & Gobbi, G. (2014). CCNP Award Paper: Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology. Journal of Psychiatry and Neuroscience, 39(1), 6-21.
Posa, Luca, Danilo De Gregorio, Gabriella Gobbi, and Stefano Comai. "Targeting melatonin MT2 receptors: a novel pharmacological avenue for inflammatory and neuropathic pain." Current medicinal chemistry 25, no. 32 (2018): 3866-3882.
Lopez-Canul, M., Palazzo, E., Dominguez-Lopez, S., Luongo, L., Lacoste, B., Comai, S., ... & Gobbi, G. (2015). Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways. Pain, 156(2), 305-317.
De Gregorio, D., Popic, J., Enns, J. P., Inserra, A., Skalecka, A., Markopoulos, A., ... & Gobbi, G. (2021). Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission. Proceedings of the National Academy of Sciences, 118(5), e2020705118.
De Gregorio, D., Inserra, A., Enns, J. P., Markopoulos, A., Pileggi, M., El Rahimy, Y., ... & Gobbi, G. (2022). Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline. Neuropsychopharmacology, 47(6), 1188-1198.
Aguilar-Valles, A., De Gregorio, D., Matta-Camacho, E., Eslamizade, M. J., Khlaifia, A., Skaleka, A., ... & Sonenberg, N. (2021). Antidepressant actions of ketamine engage cell-specific translation via eIF4E. Nature, 590(7845), 315-319.