Rho GTPase activating protein 26 (ARHGAP26) also known as GTPase Regulator Associated with Focal Adhesion Kinase (GRAF) is a
protein that in humans is encoded by the ARHGAP26gene.[5][6][7]
Function
GRAF1 is a multidomain protein that is necessary for the
CLIC/
GEEC endocytic pathway.[8] By virtue of an N-terminal
BAR domain, GRAF1 sculpts the endocytic membranes of this pathway into 40 nm diameter tubules and vesicles that allow uptake of extracellular fluid, GPI-linked proteins and certain bacterial exotoxins into cells. The role of
dynamin in the CLIC/GEEC pathway is controversial, but GRAF1 interacts strongly with this protein and acute inhibition of
dynamin action abrogates CLIC/GEEC
endocytosis. There are several members of the GRAF family of proteins, including
GRAF2, GRAF3, and
oligophrenin, all of which likely playing similar roles during clathrin-independent endocytic events. Mutations of both GRAF1 and oligophrenin are strongly implicated in causing human disease (
leukaemia and
mental retardation, respectively). Recently,
autoantibodies to ARHGAP26 have been implicated in autoimmune
cerebellar ataxia.[9][10][11]
^Doss S, Nümann A, Ziegler A, Siebert E, Borowski K, Stöcker W, Prüss H, Wildemann B, Endres M, Jarius S (15 Feb 2014). "Anti-Ca/anti-ARHGAP26 antibodies associated with cerebellar atrophy and cognitive decline". J. Neuroimmunol. 267 (1–2): 102–4.
doi:
10.1016/j.jneuroim.2013.10.010.
PMID24439423.
S2CID41945608.
^Shibata H, Oishi K, Yamagiwa A, Matsumoto M, Mukai H, Ono Y (2001). "PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family". J. Biochem. 130 (1): 23–31.
doi:
10.1093/oxfordjournals.jbchem.a002958.
PMID11432776.
Rho GTPase activating protein 26 (ARHGAP26) also known as GTPase Regulator Associated with Focal Adhesion Kinase (GRAF) is a
protein that in humans is encoded by the ARHGAP26gene.[5][6][7]
Function
GRAF1 is a multidomain protein that is necessary for the
CLIC/
GEEC endocytic pathway.[8] By virtue of an N-terminal
BAR domain, GRAF1 sculpts the endocytic membranes of this pathway into 40 nm diameter tubules and vesicles that allow uptake of extracellular fluid, GPI-linked proteins and certain bacterial exotoxins into cells. The role of
dynamin in the CLIC/GEEC pathway is controversial, but GRAF1 interacts strongly with this protein and acute inhibition of
dynamin action abrogates CLIC/GEEC
endocytosis. There are several members of the GRAF family of proteins, including
GRAF2, GRAF3, and
oligophrenin, all of which likely playing similar roles during clathrin-independent endocytic events. Mutations of both GRAF1 and oligophrenin are strongly implicated in causing human disease (
leukaemia and
mental retardation, respectively). Recently,
autoantibodies to ARHGAP26 have been implicated in autoimmune
cerebellar ataxia.[9][10][11]
^Doss S, Nümann A, Ziegler A, Siebert E, Borowski K, Stöcker W, Prüss H, Wildemann B, Endres M, Jarius S (15 Feb 2014). "Anti-Ca/anti-ARHGAP26 antibodies associated with cerebellar atrophy and cognitive decline". J. Neuroimmunol. 267 (1–2): 102–4.
doi:
10.1016/j.jneuroim.2013.10.010.
PMID24439423.
S2CID41945608.
^Shibata H, Oishi K, Yamagiwa A, Matsumoto M, Mukai H, Ono Y (2001). "PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family". J. Biochem. 130 (1): 23–31.
doi:
10.1093/oxfordjournals.jbchem.a002958.
PMID11432776.