From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Glucosamine-6-phosphate deaminase 2 also known as GNPDA2 is an
enzyme that in humans is encoded by the GNPDA2
gene .
[5]
Clinical significance
Variants of the GNPDA2 gene may be associated with
obesity .
[6]
[7]
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000163281 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000029209 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Arreola R, Valderrama B, Morante ML, Horjales E (September 2003).
"Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study" . FEBS Lett . 551 (1–3): 63–70.
doi :
10.1016/S0014-5793(03)00896-2 .
PMID
12965206 .
S2CID
45050024 .
^ Zhao J, Bradfield JP, Li M, et al. (May 2009).
"The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI" . Obesity (Silver Spring) . 17 (12): 2254–7.
doi :
10.1038/oby.2009.159 .
PMC
2860782 .
PMID
19478790 .
^ Renström F, Payne F, Nordström A, Brito EC, Rolandsson O, Hallmans G, Barroso I, Nordström P, Franks PW (April 2009).
"Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden" . Hum. Mol. Genet . 18 (8): 1489–96.
doi :
10.1093/hmg/ddp041 .
PMC
2664142 .
PMID
19164386 .
^ Willer CJ, Speliotes EK, Loos RJ, et al. (January 2009).
"Six new loci associated with body mass index highlight a neuronal influence on body weight regulation" . Nat. Genet . 41 (1): 25–34.
doi :
10.1038/ng.287 .
PMC
2695662 .
PMID
19079261 .
Further reading
Bauer F, Elbers CC, Adan RA, et al. (2009).
"Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference" . Am. J. Clin. Nutr . 90 (4): 951–9.
doi :
10.3945/ajcn.2009.27781 .
PMID
19692490 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Haupt A, Thamer C, Heni M, et al. (2009).
"Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study" . Obesity (Silver Spring) . 18 (6): 1212–7.
doi :
10.1038/oby.2009.413 .
PMID
19910938 .
S2CID
9601431 .
Li S, Zhao JH, Luan J, et al. (2010).
"Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies" . Am. J. Clin. Nutr . 91 (1): 184–90.
doi :
10.3945/ajcn.2009.28403 .
PMID
19812171 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Brandys MK, van Elburg AA, Loos RJ, et al. (2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". Am. J. Med. Genet. B Neuropsychiatr. Genet . 153B (2): 695–9.
doi :
10.1002/ajmg.b.31026 .
PMID
19746409 .
S2CID
45793585 .
Renström F, Payne F, Nordström A, et al. (2009).
"Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden" . Hum. Mol. Genet . 18 (8): 1489–96.
doi :
10.1093/hmg/ddp041 .
PMC
2664142 .
PMID
19164386 .
He M, Cornelis MC, Franks PW, et al. (2010).
"Obesity Genotype Score and Cardiovascular Risk in Women with Type 2 Diabetes" . Arterioscler. Thromb. Vasc. Biol . 30 (2): 327–32.
doi :
10.1161/ATVBAHA.109.196196 .
PMC
3061473 .
PMID
19910641 .
Barbe L, Lundberg E, Oksvold P, et al. (2008).
"Toward a confocal subcellular atlas of the human proteome" . Mol. Cell. Proteomics . 7 (3): 499–508.
doi :
10.1074/mcp.M700325-MCP200 .
PMID
18029348 .
Hotta K, Nakamura M, Nakamura T, et al. (2009).
"Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population" . J. Hum. Genet . 54 (12): 727–31.
doi :
10.1038/jhg.2009.106 .
PMID
19851340 .