glycosylation dependent cell adhesion molecule-1 | |||||||
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Identifiers | |||||||
Symbol | GLYCAM1 | ||||||
NCBI gene | 644076 | ||||||
HGNC | 18023 | ||||||
RefSeq | XM_927461 | ||||||
UniProt | Q8IVK1 | ||||||
Other data | |||||||
Locus | Chr. 12 q13.2 | ||||||
|
Glycosylation-dependent cell adhesion molecule-1 (GLYCAM1) is a proteoglycan ligand expressed on cells of the high endothelial venules in lymphoid tissues. It is the ligand for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues. [1] [2] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.[ citation needed] Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex. [3]
GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region. [1]
glycosylation dependent cell adhesion molecule-1 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | GLYCAM1 | ||||||
NCBI gene | 644076 | ||||||
HGNC | 18023 | ||||||
RefSeq | XM_927461 | ||||||
UniProt | Q8IVK1 | ||||||
Other data | |||||||
Locus | Chr. 12 q13.2 | ||||||
|
Glycosylation-dependent cell adhesion molecule-1 (GLYCAM1) is a proteoglycan ligand expressed on cells of the high endothelial venules in lymphoid tissues. It is the ligand for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues. [1] [2] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.[ citation needed] Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex. [3]
GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region. [1]