From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Growth differentiation factor 1 (GDF1) is a
protein that in humans is encoded by the GDF1
gene .
[5]
GDF1 belongs to the
transforming growth factor beta superfamily that has a role in left-right patterning and
mesoderm
induction during
embryonic development .
[6] It is found in the brain, spinal cord and peripheral nerves of embryos.
[5]
[6]
Jiang JC, Kirchman PA, Zagulski M, et al. (1998).
"Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human" . Genome Res . 8 (12): 1259–72.
doi :
10.1101/gr.8.12.1259 .
PMID
9872981 .
Lee SJ (1990).
"Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily" . Mol. Endocrinol . 4 (7): 1034–40.
doi :
10.1210/mend-4-7-1034 .
PMID
1704486 .
Li J, Jia H, Xie L, et al. (2009). "Correlation of inhibitor of differentiation 1 expression to tumor progression, poor differentiation and aggressive behaviors in cervical carcinoma". Gynecol. Oncol . 114 (1): 89–93.
doi :
10.1016/j.ygyno.2009.03.016 .
PMID
19359031 .
Ducy P, Karsenty G (2000).
"The family of bone morphogenetic proteins" . Kidney Int . 57 (6): 2207–14.
doi :
10.1046/j.1523-1755.2000.00081.x .
PMID
10844590 .
Lee SJ (1991).
"Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure" . Proc. Natl. Acad. Sci. U.S.A . 88 (10): 4250–4.
Bibcode :
1991PNAS...88.4250L .
doi :
10.1073/pnas.88.10.4250 .
PMC
51636 .
PMID
2034669 .
Roessler E, Pei W, Ouspenskaia MV, et al. (2009).
"Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly" . Mol. Genet. Metab . 98 (1–2): 225–34.
doi :
10.1016/j.ymgme.2009.05.005 .
PMC
2774839 .
PMID
19553149 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Grimwood J, Gordon LA, Olsen A, et al. (2004).
"The DNA sequence and biology of human chromosome 19" . Nature . 428 (6982): 529–35.
Bibcode :
2004Natur.428..529G .
doi :
10.1038/nature02399 .
PMID
15057824 .
Karkera JD, Lee JS, Roessler E, et al. (2007).
"Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in humans" . Am. J. Hum. Genet . 81 (5): 987–94.
doi :
10.1086/522890 .
PMC
2265655 .
PMID
17924340 .
Polymeropoulos MH, Xiao H, Sikela JM, et al. (1993). "Chromosomal distribution of 320 genes from a brain cDNA library". Nat. Genet . 4 (4): 381–6.
doi :
10.1038/ng0893-381 .
PMID
8401586 .
S2CID
33426184 .
Type I
ALK1 (
ACVRL1 )
ALK2 (
ACVR1A )
ALK3 (
BMPR1A )
ALK4 (
ACVR1B )
ALK5 (
TGFβR1 )
ALK6 (
BMPR1B )
Agonists:
BMP (
2 ,
4 ,
5 ,
6 ,
7 ,
8A ,
8B ,
15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (
5 (BMP14) ,
6 (BMP13) ,
7 (BMP12) ,
9 ,
15 )
Radotermin
ALK7 (
ACVR1C )
Type II
TGFβR2
BMPR2
ACVR2A (
ACVR2 )
Agonists:
Activin (
A ,
B ,
AB )
BMP (
2 ,
4 ,
5 ,
6 ,
7 ,
8A ,
8B ,
15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (
1 ,
3 ,
5 (BMP14) ,
6 (BMP13) ,
7 (BMP12) ,
9 ,
11 (BMP11) ,
15 )
Myostatin (GDF8)
Nodal
Radotermin
ACVR2B
Agonists:
Activin (
A ,
B ,
AB )
BMP (
2 ,
4 ,
6 ,
7 )
Dibotermin alfa
Eptotermin alfa
GDF (
1 ,
3 ,
5 (BMP14) ,
6 (BMP13) ,
7 (BMP12) )
Myostatin (GDF8)
Nodal
Osteogenin (BMP3, BMP3A)
Radotermin
AMHR2 (
AMHR )
Type III
Unsorted