N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase is an
enzyme that in humans is encoded by the GCNT2gene.[5][6][7]
This gene encodes the enzyme responsible for formation of the
blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a
beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in
erythrocytes during
embryonic development. Mutations in this gene have been associated with adult i blood group
phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.[7]
Keats B, Ott J, Conneally M (1989). "Report of the committee on linkage and gene order". Cytogenet. Cell Genet. 51 (1–4): 459–502.
doi:
10.1159/000132805.
PMID2791656.
Bierhuizen MF, Maemura K, Kudo S, Fukuda M (1995). "Genomic organization of core 2 and I branching beta-1,6-N-acetylglucosaminyltransferases. Implication for evolution of the beta-1,6-N-acetylglucosaminyltransferase gene family". Glycobiology. 5 (4): 417–25.
doi:
10.1093/glycob/5.4.417.
PMID7579796.
Olavesen MG, Bentley E, Mason RV, et al. (1998). "Fine mapping of 39 ESTs on human chromosome 6p23-p25". Genomics. 46 (2): 303–6.
doi:
10.1006/geno.1997.5032.
PMID9417921.
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase is an
enzyme that in humans is encoded by the GCNT2gene.[5][6][7]
This gene encodes the enzyme responsible for formation of the
blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a
beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in
erythrocytes during
embryonic development. Mutations in this gene have been associated with adult i blood group
phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.[7]
Keats B, Ott J, Conneally M (1989). "Report of the committee on linkage and gene order". Cytogenet. Cell Genet. 51 (1–4): 459–502.
doi:
10.1159/000132805.
PMID2791656.
Bierhuizen MF, Maemura K, Kudo S, Fukuda M (1995). "Genomic organization of core 2 and I branching beta-1,6-N-acetylglucosaminyltransferases. Implication for evolution of the beta-1,6-N-acetylglucosaminyltransferase gene family". Glycobiology. 5 (4): 417–25.
doi:
10.1093/glycob/5.4.417.
PMID7579796.
Olavesen MG, Bentley E, Mason RV, et al. (1998). "Fine mapping of 39 ESTs on human chromosome 6p23-p25". Genomics. 46 (2): 303–6.
doi:
10.1006/geno.1997.5032.
PMID9417921.