GAF domain | |||||||||
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![]() 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains.
[1] | |||||||||
Identifiers | |||||||||
Symbol | GAF | ||||||||
Pfam | PF01590 | ||||||||
Pfam clan | CL0161 | ||||||||
InterPro | IPR003018 | ||||||||
SMART | GAF | ||||||||
SCOP2 | 1fl4 / SCOPe / SUPFAM | ||||||||
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The GAF domain is a type of protein domain that is found in a wide range of proteins from all species. [2] The GAF domain is named after some of the proteins it is found in: cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. The first structure of a GAF domain solved by Ho and colleagues showed that this domain shared a similar fold with the PAS domain. [3] In mammals, GAF domains are found in five members of the cyclic nucleotide phosphodiesterase superfamily: PDE2, PDE5, and PDE6 which bind cGMP to the GAF domain, PDE10 which binds cAMP, and PDE11 which binds both cGMP and cAMP. [4] [5]
Human proteins containing this domain include:
GAF domain | |||||||||
---|---|---|---|---|---|---|---|---|---|
![]() 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains.
[1] | |||||||||
Identifiers | |||||||||
Symbol | GAF | ||||||||
Pfam | PF01590 | ||||||||
Pfam clan | CL0161 | ||||||||
InterPro | IPR003018 | ||||||||
SMART | GAF | ||||||||
SCOP2 | 1fl4 / SCOPe / SUPFAM | ||||||||
|
The GAF domain is a type of protein domain that is found in a wide range of proteins from all species. [2] The GAF domain is named after some of the proteins it is found in: cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. The first structure of a GAF domain solved by Ho and colleagues showed that this domain shared a similar fold with the PAS domain. [3] In mammals, GAF domains are found in five members of the cyclic nucleotide phosphodiesterase superfamily: PDE2, PDE5, and PDE6 which bind cGMP to the GAF domain, PDE10 which binds cAMP, and PDE11 which binds both cGMP and cAMP. [4] [5]
Human proteins containing this domain include: