Glutamate decarboxylase 2 is an
enzyme that in humans is encoded by the GAD2gene.[5]
This gene encodes one of several forms of
glutamic acid decarboxylase, identified as a major
autoantigen in insulin-dependent
diabetes. The enzyme encoded is responsible for catalyzing the production of
gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this
enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive
T cell target in insulin-dependent diabetes. This gene may also play a role in the
stiff-person syndrome.[6]
Glutamate decarboxylase 2 is an
enzyme that in humans is encoded by the GAD2gene.[5]
This gene encodes one of several forms of
glutamic acid decarboxylase, identified as a major
autoantigen in insulin-dependent
diabetes. The enzyme encoded is responsible for catalyzing the production of
gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this
enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive
T cell target in insulin-dependent diabetes. This gene may also play a role in the
stiff-person syndrome.[6]