Fungal immunomodulatory protein | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||
Symbol | FIP | ||||||||||
Pfam | PF09259 | ||||||||||
InterPro | IPR015339 | ||||||||||
|
Fungal immunomodulatory proteins (FIPs) are a type of functional compound (other compounds include polysaccharides and triterpenoids) found in various species of fungi. FIPs are part of the immunoglobulin (ig) family, which are structurally similar to human antibodies, and can interact with human peripheral blood mononuclear cells (PBMCs), causing these cells to secrete different types of hormones and regulate cellular activity. [1]
The first FIP was discovered in 1989 by Japanese scientist Kohsuke Kino et al. from the water extract of the mycelium of Ganoderma lucidum, and was named Ling Zhi-8 (LZ-8). [2]
From then on, researchers have identified numerous structurally similar proteins from various types of fungi that also share a high degree of genetic similarity as well as physiological activities, and thus coined the term fungal immunomodulatory protein (FIP). [3]
Currently known FIPs [3] are listed below:
Fungal immunomodulatory protein | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||
Symbol | FIP | ||||||||||
Pfam | PF09259 | ||||||||||
InterPro | IPR015339 | ||||||||||
|
Fungal immunomodulatory proteins (FIPs) are a type of functional compound (other compounds include polysaccharides and triterpenoids) found in various species of fungi. FIPs are part of the immunoglobulin (ig) family, which are structurally similar to human antibodies, and can interact with human peripheral blood mononuclear cells (PBMCs), causing these cells to secrete different types of hormones and regulate cellular activity. [1]
The first FIP was discovered in 1989 by Japanese scientist Kohsuke Kino et al. from the water extract of the mycelium of Ganoderma lucidum, and was named Ling Zhi-8 (LZ-8). [2]
From then on, researchers have identified numerous structurally similar proteins from various types of fungi that also share a high degree of genetic similarity as well as physiological activities, and thus coined the term fungal immunomodulatory protein (FIP). [3]
Currently known FIPs [3] are listed below: