From Wikipedia, the free encyclopedia
(Redirected from FlmB RNA)
flmB
Conserved secondary structure of flmB RNA.
Identifiers
SymbolFlmB
Other data
RNA type antisense RNA
Domain(s) E. coli, S. enterica
PDB structures PDBe

The FlmA-FlmB toxin-antitoxin system consists of FlmB RNA (F leading-region maintenance B), a family of non-coding RNAs and the protein toxin FlmA. The FlmB RNA transcript is 100 nucleotides in length and is homologous to sok RNA from the hok/sok system and fulfills the identical function as a post-segregational killing (PSK) mechanism. [1] [2]

flmB is found on the F-plasmid of Escherichia coli and Salmonella enterica. It is responsible for stabilising the plasmid. If the plasmid is not inherited, long-lived FlmA mRNA and protein will be highly toxic to the cell, possibly to the point of causing cell death. [2] Daughter cells which inherit the plasmid inherit the FlmB gene, coding for FlmB RNA which binds the leader sequence of FlmA mRNA and represses its translation. [1]

See also

References

  1. ^ a b Loh SM, Cram DS, Skurray RA (June 1988). "Nucleotide sequence and transcriptional analysis of a third function (Flm) involved in F-plasmid maintenance". Gene. 66 (2): 259–268. doi: 10.1016/0378-1119(88)90362-9. PMID  3049248.
  2. ^ a b Kobayashi M, Kurusu Y, Yukawa H (February 1991). "High-expression of a target gene and high-stability of the plasmid". Appl. Biochem. Biotechnol. 27 (2): 145–162. doi: 10.1007/BF02921523. PMID  2029184. S2CID  41601297.

Further reading

From Wikipedia, the free encyclopedia
(Redirected from FlmB RNA)
flmB
Conserved secondary structure of flmB RNA.
Identifiers
SymbolFlmB
Other data
RNA type antisense RNA
Domain(s) E. coli, S. enterica
PDB structures PDBe

The FlmA-FlmB toxin-antitoxin system consists of FlmB RNA (F leading-region maintenance B), a family of non-coding RNAs and the protein toxin FlmA. The FlmB RNA transcript is 100 nucleotides in length and is homologous to sok RNA from the hok/sok system and fulfills the identical function as a post-segregational killing (PSK) mechanism. [1] [2]

flmB is found on the F-plasmid of Escherichia coli and Salmonella enterica. It is responsible for stabilising the plasmid. If the plasmid is not inherited, long-lived FlmA mRNA and protein will be highly toxic to the cell, possibly to the point of causing cell death. [2] Daughter cells which inherit the plasmid inherit the FlmB gene, coding for FlmB RNA which binds the leader sequence of FlmA mRNA and represses its translation. [1]

See also

References

  1. ^ a b Loh SM, Cram DS, Skurray RA (June 1988). "Nucleotide sequence and transcriptional analysis of a third function (Flm) involved in F-plasmid maintenance". Gene. 66 (2): 259–268. doi: 10.1016/0378-1119(88)90362-9. PMID  3049248.
  2. ^ a b Kobayashi M, Kurusu Y, Yukawa H (February 1991). "High-expression of a target gene and high-stability of the plasmid". Appl. Biochem. Biotechnol. 27 (2): 145–162. doi: 10.1007/BF02921523. PMID  2029184. S2CID  41601297.

Further reading


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