flmB | |
---|---|
![]() Conserved secondary structure of flmB RNA. | |
Identifiers | |
Symbol | FlmB |
Other data | |
RNA type | antisense RNA |
Domain(s) | E. coli, S. enterica |
PDB structures | PDBe |
The FlmA-FlmB toxin-antitoxin system consists of FlmB RNA (F leading-region maintenance B), a family of non-coding RNAs and the protein toxin FlmA. The FlmB RNA transcript is 100 nucleotides in length and is homologous to sok RNA from the hok/sok system and fulfills the identical function as a post-segregational killing (PSK) mechanism. [1] [2]
flmB is found on the F-plasmid of Escherichia coli and Salmonella enterica. It is responsible for stabilising the plasmid. If the plasmid is not inherited, long-lived FlmA mRNA and protein will be highly toxic to the cell, possibly to the point of causing cell death. [2] Daughter cells which inherit the plasmid inherit the FlmB gene, coding for FlmB RNA which binds the leader sequence of FlmA mRNA and represses its translation. [1]
flmB | |
---|---|
![]() Conserved secondary structure of flmB RNA. | |
Identifiers | |
Symbol | FlmB |
Other data | |
RNA type | antisense RNA |
Domain(s) | E. coli, S. enterica |
PDB structures | PDBe |
The FlmA-FlmB toxin-antitoxin system consists of FlmB RNA (F leading-region maintenance B), a family of non-coding RNAs and the protein toxin FlmA. The FlmB RNA transcript is 100 nucleotides in length and is homologous to sok RNA from the hok/sok system and fulfills the identical function as a post-segregational killing (PSK) mechanism. [1] [2]
flmB is found on the F-plasmid of Escherichia coli and Salmonella enterica. It is responsible for stabilising the plasmid. If the plasmid is not inherited, long-lived FlmA mRNA and protein will be highly toxic to the cell, possibly to the point of causing cell death. [2] Daughter cells which inherit the plasmid inherit the FlmB gene, coding for FlmB RNA which binds the leader sequence of FlmA mRNA and represses its translation. [1]