The Five-choice serial-reaction time task (5CSRTT) is a laboratory behavioral task used in psychological research to assess visuospatial attention and motor impulsivity in animals. [1] [2] The task takes place within an operant chamber equipped with at least five holes (apertures) that can illuminate, and a food tray to deliver reward. The 5CSRTT requires the animal (typically a rat, although mice can also be used [3]) to correctly identify which of the five apertures has been briefly illuminated, via a nose poke, in order to receive a sugar reward. The difficulty of the task is controlled by the length of time the aperture is illuminated: a shorter illumination time requires the animal to pay greater attention, and thus is more difficult (as shown by decreased accuracy). [4] Between every trial, there is also a short interval wherein the animal must withhold all responses, and any responding during this interval is met with a brief time-out and recorded as a failure of inhibitory control.
The 5CSRTT was initially designed by Trevor Robbins and colleagues in the early 1980s as an analogue of the human continuous performance task. Because the 5CSRTT has separate measures of attention, impulsivity, and reaction times, it has proven useful in the pre-clinical study of the treatment of diagnoses such as attention-deficit/hyperactivity disorder, [5] and is also a precursor to modern rodent models of gambling [6] and decision making. [7]
See also
References
- ^ Robbins, TW (October 2002). "The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry". Psychopharmacology. 163 (3–4): 362–80. doi: 10.1007/s00213-002-1154-7. PMID 12373437. S2CID 8851263.
- ^ Bari, A (2008). "The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats". Nature Protocols. 3 (5): 759–67. doi: 10.1038/nprot.2008.41. PMID 18451784. S2CID 22001279. Retrieved 8 March 2010.
- ^ Lustig, C (2013). "CNTRICS final animal model task selection: control of attention". Neuroscience & Biobehavioral Reviews. 37 (9B): 2099–2110. doi: 10.1016/j.neubiorev.2012.05.009. PMC 3490036. PMID 22683929.
- ^ Dalley, JW (2004). "Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates". Neuroscience and Biobehavioral Reviews. 28 (7): 771–84. doi: 10.1016/j.neubiorev.2004.09.006. PMID 15555683. S2CID 8780239.
- ^ Robinson, Emma SJ. "Similar Effects of the Selective Noradrenaline Reuptake" (PDF). npb. Retrieved 6 May 2011.
- ^ Zeeb, Fiona SJ. "Serotonergic and Dopaminergic Modulation of Gambling Behavior as Assessed Using a Novel Rat Gambling Task". npp. Retrieved 2 July 2014.
-
^ Cocker, Hosking, Paul, Jay SJ (2012).
"Sensitivity to Cognitive Effort Mediates Psychostimulant Effects on a Novel Rodent Cost/Benefit Decision-Making Task". Neuropsychopharmacology. 37 (8). npp: 1825–37.
doi:
10.1038/npp.2012.30.
PMC
3376315.
PMID
22453140.
{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
The Five-choice serial-reaction time task (5CSRTT) is a laboratory behavioral task used in psychological research to assess visuospatial attention and motor impulsivity in animals. [1] [2] The task takes place within an operant chamber equipped with at least five holes (apertures) that can illuminate, and a food tray to deliver reward. The 5CSRTT requires the animal (typically a rat, although mice can also be used [3]) to correctly identify which of the five apertures has been briefly illuminated, via a nose poke, in order to receive a sugar reward. The difficulty of the task is controlled by the length of time the aperture is illuminated: a shorter illumination time requires the animal to pay greater attention, and thus is more difficult (as shown by decreased accuracy). [4] Between every trial, there is also a short interval wherein the animal must withhold all responses, and any responding during this interval is met with a brief time-out and recorded as a failure of inhibitory control.
The 5CSRTT was initially designed by Trevor Robbins and colleagues in the early 1980s as an analogue of the human continuous performance task. Because the 5CSRTT has separate measures of attention, impulsivity, and reaction times, it has proven useful in the pre-clinical study of the treatment of diagnoses such as attention-deficit/hyperactivity disorder, [5] and is also a precursor to modern rodent models of gambling [6] and decision making. [7]
See also
References
- ^ Robbins, TW (October 2002). "The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry". Psychopharmacology. 163 (3–4): 362–80. doi: 10.1007/s00213-002-1154-7. PMID 12373437. S2CID 8851263.
- ^ Bari, A (2008). "The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats". Nature Protocols. 3 (5): 759–67. doi: 10.1038/nprot.2008.41. PMID 18451784. S2CID 22001279. Retrieved 8 March 2010.
- ^ Lustig, C (2013). "CNTRICS final animal model task selection: control of attention". Neuroscience & Biobehavioral Reviews. 37 (9B): 2099–2110. doi: 10.1016/j.neubiorev.2012.05.009. PMC 3490036. PMID 22683929.
- ^ Dalley, JW (2004). "Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates". Neuroscience and Biobehavioral Reviews. 28 (7): 771–84. doi: 10.1016/j.neubiorev.2004.09.006. PMID 15555683. S2CID 8780239.
- ^ Robinson, Emma SJ. "Similar Effects of the Selective Noradrenaline Reuptake" (PDF). npb. Retrieved 6 May 2011.
- ^ Zeeb, Fiona SJ. "Serotonergic and Dopaminergic Modulation of Gambling Behavior as Assessed Using a Novel Rat Gambling Task". npp. Retrieved 2 July 2014.
-
^ Cocker, Hosking, Paul, Jay SJ (2012).
"Sensitivity to Cognitive Effort Mediates Psychostimulant Effects on a Novel Rodent Cost/Benefit Decision-Making Task". Neuropsychopharmacology. 37 (8). npp: 1825–37.
doi:
10.1038/npp.2012.30.
PMC
3376315.
PMID
22453140.
{{ cite journal}}: CS1 maint: multiple names: authors list ( link)