Face of the giant panda sign | |
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Axial T2-weighted MRI of the brain at the level of the midbrain showing the characteristic ‘face of the giant panda’ sign, with normal red nuclei and substantia nigra (pars reticulata) against a background of hyperintensity in the tegmentum, as well as hypointensity of the superior colliculi | |
Complications | choreoathetosis |
Differential diagnosis | Wilson's disease, Wernicke's encephalopathy, Leigh syndrome, acute disseminated encephalomyelitis, toxic leukoencephalopathy, rabies |
Medication | penicillamine, thiamine, corticosteroids |
The face of the giant panda sign, panda sign of the midbrain or double-panda sign is a characteristic "panda's face" appearance in magnetic resonance imaging (MRI) images of people with Wilson's disease. Along with Kayser–Fleischer rings, the sign is helpful in diagnosis. [1]
While the sign is most common in Wilson's disease, it has been rarely reported in acute disseminated encephalomyelitis, [2] rabies encephalopathy, [3] toxic leukoencephalopathy [4] and Leigh syndrome. [5]
Face of the giant panda sign | |
---|---|
Axial T2-weighted MRI of the brain at the level of the midbrain showing the characteristic ‘face of the giant panda’ sign, with normal red nuclei and substantia nigra (pars reticulata) against a background of hyperintensity in the tegmentum, as well as hypointensity of the superior colliculi | |
Complications | choreoathetosis |
Differential diagnosis | Wilson's disease, Wernicke's encephalopathy, Leigh syndrome, acute disseminated encephalomyelitis, toxic leukoencephalopathy, rabies |
Medication | penicillamine, thiamine, corticosteroids |
The face of the giant panda sign, panda sign of the midbrain or double-panda sign is a characteristic "panda's face" appearance in magnetic resonance imaging (MRI) images of people with Wilson's disease. Along with Kayser–Fleischer rings, the sign is helpful in diagnosis. [1]
While the sign is most common in Wilson's disease, it has been rarely reported in acute disseminated encephalomyelitis, [2] rabies encephalopathy, [3] toxic leukoencephalopathy [4] and Leigh syndrome. [5]