Home • Search • Translate
From Wikipedia, the free encyclopedia
This article is about the term as it applies to neuroscience. For the type of electronic wavefunction in atomic physics, see atomic orbital.

In neuroscience, an F wave is one of several motor responses which may follow the direct motor response (M) evoked by electrical stimulation of peripheral motor or mixed (sensory and motor) nerves. [1] F-waves are the second of two late voltage changes observed after stimulation is applied to the skin surface above the distal region of a nerve, in addition to the H-reflex (Hoffman's Reflex) which is a muscle reaction in response to electrical stimulation of innervating sensory fibers. [2] [3] Traversal of F-waves along the entire length of peripheral nerves between the spinal cord and muscle, allows for assessment of motor nerve conduction between distal stimulation sites in the arm and leg, and related motoneurons (MN's) in the cervical and lumbosacral cord. [4] F-waves are able to assess both afferent and efferent loops of the alpha motor neuron in its entirety. [5] As such, various properties of F-wave motor nerve conduction are analyzed in nerve conduction studies (NCS), [6] and often used to assess polyneuropathies, resulting from states of neuronal demyelination and loss of peripheral axonal integrity. [1] [7] [8]

With respect to its nomenclature, the F-wave is so named as it was initially studied in the smaller muscles of the foot. [9] The observation of F-waves in the same motor units (MU) as those present in the direct motor response (M), [10] along with the presence of F-waves in deafferented animal and human models, [11] indicates that F-waves require direct activation of motor axons to be elicited, [12] and do not involve conduction along afferent sensory nerves. Thus, the F-wave is considered a wave, as opposed to a reflex.

Physiology

F-waves are evoked by strong electrical stimuli (supramaximal) applied to the skin surface above the distal portion of a nerve. [3] This impulse travels both in orthodromic fashion (towards the muscle fibers) and antidromic fashion (towards the cell body in the spinal cord) along the alpha motor neuron. [4] [7] [13] [14] As the orthodromic impulse reaches innervated muscle fibers, a strong direct motor response (M) is evoked in these muscle fibers, resulting in a primary compound muscle action potential (CMAP). [3] [7] As the antidromic impulse reaches the cell bodies within the anterior horn of the motor neuron pool by retrograde transmission, a select portion of these alpha motor neurons, (roughly 5-10% of available motor neurons), 'backfire' or rebound. [2] [3] [4] [5] This antidromic 'backfiring' elicits an orthodromic impulse that follows back down the alpha motor neuron, towards innervated muscle fibers. Conventionally, axonal segments of motor neurons previously depolarized by preceding antidromic impulses enter a hyperpolarized state, disallowing the travel of impulses along them. [15] However, these same axonal segments remains excitable or relatively depolarized for a sufficient period of time, allowing for rapid antidromic backfiring, and thus the continuation of the orthodromic impulse towards innervated muscle fibers. [15] [13] This successive orthodromic stimulus then evokes a smaller population of muscle fibers, resulting in a smaller CMAP known as an F-wave. [3]

Several physiological factors may possibly influence the presence of F-waves after peripheral nerve stimulation. The shape and size of F-waves, along with the probability of their presence is small, as a high degree of variability exists in motor unit (MU) activation for any given stimulation. [4] Thus, the generation of CMAP's which elicit F-waves is subject to the variability in activation of motor units in a given pool over successive stimuli. [11] Moreover, stimulation of peripheral nerve fibers account for both orthodromic impulses (along sensory fibers, towards the dorsal horn), as well as antidromic activity (along alpha motor neurons towards the ventral horn). [4] Antidromic activity along collateral branches of alpha motor neurons may result in the activation of inhibitory Renshaw cells or direct inhibitory collaterals between motorneurons. [16] Inhibition by these means may lower excitability of adjacent motor neurons and decrease the potential for antidromic backfiring and resultant F-waves; although it has been argued Renshaw cells preferentially inhibit smaller alpha motor neurons limited influence on modulation of antidromic backfiring. [7]

Because a different population of anterior horn cells is stimulated with each stimulation, F waves are characterized as ubiquitous, low amplitude, late motor responses, which can vary in amplitude, latency and configuration across a series of stimuli. [4] [17]

Properties

F waves can be analyzed by several properties including:

  • amplitude ( μV) - height or voltage of F wave
  • duration ( ms) - length of F wave
  • latency ( ms) - period between initial stimulation and F wave elicitation

Measurements

Several measurements can be done on the F responses, including: [7] [13]

  • minimal and maximal F wave latencies (ms) - frequently used in the assessment of demyelinating neuropathic conditions including Guillain-Barré syndrome.
  • chronodispersion - difference in maximal and minimal latencies across a series of F waves
  • F wave persistence - measure of alpha motor neuron excitability calculated as the number of F responses elicited divided by the number of stimuli presented.

The minimal F wave latency is typically 25-32 ms in the upper extremities and 45-56 ms in the lower extremities.

F wave persistence is the number of F waves obtained per the number of stimulations, which is normally 80-100% (or above 50%).

See also

References

  1. ^ a b Neuromuscular function and disease : basic, clinical, and electrodiagnostic aspects. Brown, William F. (William Frederick), 1939-, Bolton, Charles Francis, 1932-, Aminoff, Michael J. (Michael Jeffrey) (1st ed.). Philadelphia: Saunders. 2002. ISBN  0-7216-8922-1. OCLC  46873002.{{ cite book}}: CS1 maint: others ( link)
  2. ^ a b Smith, M; Kofke, WA; Citerio, G (2016). Oxford Textbook of Neurocritical Care. Oxford University Press. p. 175.
  3. ^ a b c d e Jerath, Nivedita; Kimura, Jun (2019). "F wave, A wave, H reflex, and blink reflex". Clinical Neurophysiology: Basis and Technical Aspects. Handbook of Clinical Neurology. Vol. 160. pp. 225–239. doi: 10.1016/B978-0-444-64032-1.00015-1. ISBN  9780444640321. ISSN  0072-9752. PMID  31277850. S2CID  195813560.
  4. ^ a b c d e f Fisher, Morris A. (2007-02-02). "F-waves--physiology and clinical uses". TheScientificWorldJournal. 7: 144–160. doi: 10.1100/tsw.2007.49. ISSN  1537-744X. PMC  5901048. PMID  17334607.
  5. ^ a b Katirji, Bashar. (2007). Electromyography in clinical practice : a case study approach (2nd ed.). Philadelphia: Mosby Elsevier. ISBN  978-0-323-07034-8. OCLC  324995633.
  6. ^ Mallik, A.; Weir, A. I. (2005). "Nerve conduction studies: essentials and pitfalls in practice". Journal of Neurology, Neurosurgery, and Psychiatry. 76 (Suppl 2): ii23–31. doi: 10.1136/jnnp.2005.069138. ISSN  0022-3050. PMC  1765692. PMID  15961865.
  7. ^ a b c d e Fisher, Morris A. (1992). "AAEM minimonograph #13: H reflexes and F waves: Physiology and clinical indications". Muscle & Nerve. 15 (11): 1223–1233. doi: 10.1002/mus.880151102. ISSN  1097-4598. PMID  1488060. S2CID  6174526.
  8. ^ Lachman, T; Shahani, B T; Young, R R (1980). "Late responses as aids to diagnosis in peripheral neuropathy". Journal of Neurology, Neurosurgery, and Psychiatry. 43 (2): 156–162. doi: 10.1136/jnnp.43.2.156. ISSN  0022-3050. PMC  490491. PMID  6244369.
  9. ^ Magladery, J. W.; McDOUGAL, D. B. (1950). "Electrophysiological studies of nerve and reflex activity in normal man. I. Identification of certain reflexes in the electromyogram and the conduction velocity of peripheral nerve fibers". Bulletin of the Johns Hopkins Hospital. 86 (5): 265–290. ISSN  0097-1383. PMID  15414383.
  10. ^ Wulff, C. H.; Gilliatt, R. W. (1979). "F waves in patients with hand wasting caused by a cervical rib and band". Muscle & Nerve. 2 (6): 452–457. doi: 10.1002/mus.880020606. ISSN  0148-639X. PMID  514311. S2CID  2423723.
  11. ^ a b Fox, J E; Hitchcock, E R (1987). "F wave size as a monitor of motor neuron excitability: the effect of deafferentation". Journal of Neurology, Neurosurgery, and Psychiatry. 50 (4): 453–459. doi: 10.1136/jnnp.50.4.453. ISSN  0022-3050. PMC  1031882. PMID  3585357.
  12. ^ Trontelj, JV (1973). A study of the F response by single fiber electromyography, in Desmedt JE (ed): New Developments in Electromyography and Clinical Neurophysiology. Basel: Karger. pp. 318–322.
  13. ^ a b c Panayiotopoulos, C. P.; Chroni, E. (1996). "F-waves in clinical neurophysiology: a review, methodological issues and overall value in peripheral neuropathies". Electroencephalography and Clinical Neurophysiology. 101 (5): 365–374. ISSN  0013-4694. PMID  8913188.
  14. ^ Sathya, G. R.; Krishnamurthy, N.; Veliath, Susheela; Arulneyam, Jayanthi; Venkatachalam, J. (2017). "F wave index: A diagnostic tool for peripheral neuropathy". The Indian Journal of Medical Research. 145 (3): 353–357. doi: 10.4103/ijmr.IJMR_1087_14 (inactive 31 January 2024). ISSN  0971-5916. PMC  5555064. PMID  28749398.{{ cite journal}}: CS1 maint: DOI inactive as of January 2024 ( link)
  15. ^ a b Kimura, Jun (2004-01-01). "Peripheral nerve conduction studies and neuromuscular junction testing". In Eisen, Andrew (ed.). Clinical Neurophysiology of Motor Neuron Diseases. Handbook of Clinical Neurophysiology. Vol. 4. Elsevier. pp. 241–270. doi: 10.1016/S1567-4231(04)04012-2. ISBN  9780444513595. Retrieved 2020-02-26.
  16. ^ Moore, Niall J.; Bhumbra, Gardave S.; Foster, Joshua D.; Beato, Marco (2015-10-07). "Synaptic Connectivity between Renshaw Cells and Motoneurons in the Recurrent Inhibitory Circuit of the Spinal Cord". The Journal of Neuroscience. 35 (40): 13673–13686. doi: 10.1523/JNEUROSCI.2541-15.2015. ISSN  0270-6474. PMC  4595620. PMID  26446220.
  17. ^ Fisher, Morris A.; Patil, Vijaya K.; Webber, Charles L. (2015). "Recurrence Quantification Analysis of F-Waves and the Evaluation of Neuropathies". Neurology Research International. 2015: 183608. doi: 10.1155/2015/183608. ISSN  2090-1852. PMC  4672360. PMID  26688754.
Retrieved from " https://en.wikipedia.org/?title=F_wave&oldid=1201887777"
From Wikipedia, the free encyclopedia
This article is about the term as it applies to neuroscience. For the type of electronic wavefunction in atomic physics, see atomic orbital.

In neuroscience, an F wave is one of several motor responses which may follow the direct motor response (M) evoked by electrical stimulation of peripheral motor or mixed (sensory and motor) nerves. [1] F-waves are the second of two late voltage changes observed after stimulation is applied to the skin surface above the distal region of a nerve, in addition to the H-reflex (Hoffman's Reflex) which is a muscle reaction in response to electrical stimulation of innervating sensory fibers. [2] [3] Traversal of F-waves along the entire length of peripheral nerves between the spinal cord and muscle, allows for assessment of motor nerve conduction between distal stimulation sites in the arm and leg, and related motoneurons (MN's) in the cervical and lumbosacral cord. [4] F-waves are able to assess both afferent and efferent loops of the alpha motor neuron in its entirety. [5] As such, various properties of F-wave motor nerve conduction are analyzed in nerve conduction studies (NCS), [6] and often used to assess polyneuropathies, resulting from states of neuronal demyelination and loss of peripheral axonal integrity. [1] [7] [8]

With respect to its nomenclature, the F-wave is so named as it was initially studied in the smaller muscles of the foot. [9] The observation of F-waves in the same motor units (MU) as those present in the direct motor response (M), [10] along with the presence of F-waves in deafferented animal and human models, [11] indicates that F-waves require direct activation of motor axons to be elicited, [12] and do not involve conduction along afferent sensory nerves. Thus, the F-wave is considered a wave, as opposed to a reflex.

Physiology

F-waves are evoked by strong electrical stimuli (supramaximal) applied to the skin surface above the distal portion of a nerve. [3] This impulse travels both in orthodromic fashion (towards the muscle fibers) and antidromic fashion (towards the cell body in the spinal cord) along the alpha motor neuron. [4] [7] [13] [14] As the orthodromic impulse reaches innervated muscle fibers, a strong direct motor response (M) is evoked in these muscle fibers, resulting in a primary compound muscle action potential (CMAP). [3] [7] As the antidromic impulse reaches the cell bodies within the anterior horn of the motor neuron pool by retrograde transmission, a select portion of these alpha motor neurons, (roughly 5-10% of available motor neurons), 'backfire' or rebound. [2] [3] [4] [5] This antidromic 'backfiring' elicits an orthodromic impulse that follows back down the alpha motor neuron, towards innervated muscle fibers. Conventionally, axonal segments of motor neurons previously depolarized by preceding antidromic impulses enter a hyperpolarized state, disallowing the travel of impulses along them. [15] However, these same axonal segments remains excitable or relatively depolarized for a sufficient period of time, allowing for rapid antidromic backfiring, and thus the continuation of the orthodromic impulse towards innervated muscle fibers. [15] [13] This successive orthodromic stimulus then evokes a smaller population of muscle fibers, resulting in a smaller CMAP known as an F-wave. [3]

Several physiological factors may possibly influence the presence of F-waves after peripheral nerve stimulation. The shape and size of F-waves, along with the probability of their presence is small, as a high degree of variability exists in motor unit (MU) activation for any given stimulation. [4] Thus, the generation of CMAP's which elicit F-waves is subject to the variability in activation of motor units in a given pool over successive stimuli. [11] Moreover, stimulation of peripheral nerve fibers account for both orthodromic impulses (along sensory fibers, towards the dorsal horn), as well as antidromic activity (along alpha motor neurons towards the ventral horn). [4] Antidromic activity along collateral branches of alpha motor neurons may result in the activation of inhibitory Renshaw cells or direct inhibitory collaterals between motorneurons. [16] Inhibition by these means may lower excitability of adjacent motor neurons and decrease the potential for antidromic backfiring and resultant F-waves; although it has been argued Renshaw cells preferentially inhibit smaller alpha motor neurons limited influence on modulation of antidromic backfiring. [7]

Because a different population of anterior horn cells is stimulated with each stimulation, F waves are characterized as ubiquitous, low amplitude, late motor responses, which can vary in amplitude, latency and configuration across a series of stimuli. [4] [17]

Properties

F waves can be analyzed by several properties including:

  • amplitude ( μV) - height or voltage of F wave
  • duration ( ms) - length of F wave
  • latency ( ms) - period between initial stimulation and F wave elicitation

Measurements

Several measurements can be done on the F responses, including: [7] [13]

  • minimal and maximal F wave latencies (ms) - frequently used in the assessment of demyelinating neuropathic conditions including Guillain-Barré syndrome.
  • chronodispersion - difference in maximal and minimal latencies across a series of F waves
  • F wave persistence - measure of alpha motor neuron excitability calculated as the number of F responses elicited divided by the number of stimuli presented.

The minimal F wave latency is typically 25-32 ms in the upper extremities and 45-56 ms in the lower extremities.

F wave persistence is the number of F waves obtained per the number of stimulations, which is normally 80-100% (or above 50%).

See also

References

  1. ^ a b Neuromuscular function and disease : basic, clinical, and electrodiagnostic aspects. Brown, William F. (William Frederick), 1939-, Bolton, Charles Francis, 1932-, Aminoff, Michael J. (Michael Jeffrey) (1st ed.). Philadelphia: Saunders. 2002. ISBN  0-7216-8922-1. OCLC  46873002.{{ cite book}}: CS1 maint: others ( link)
  2. ^ a b Smith, M; Kofke, WA; Citerio, G (2016). Oxford Textbook of Neurocritical Care. Oxford University Press. p. 175.
  3. ^ a b c d e Jerath, Nivedita; Kimura, Jun (2019). "F wave, A wave, H reflex, and blink reflex". Clinical Neurophysiology: Basis and Technical Aspects. Handbook of Clinical Neurology. Vol. 160. pp. 225–239. doi: 10.1016/B978-0-444-64032-1.00015-1. ISBN  9780444640321. ISSN  0072-9752. PMID  31277850. S2CID  195813560.
  4. ^ a b c d e f Fisher, Morris A. (2007-02-02). "F-waves--physiology and clinical uses". TheScientificWorldJournal. 7: 144–160. doi: 10.1100/tsw.2007.49. ISSN  1537-744X. PMC  5901048. PMID  17334607.
  5. ^ a b Katirji, Bashar. (2007). Electromyography in clinical practice : a case study approach (2nd ed.). Philadelphia: Mosby Elsevier. ISBN  978-0-323-07034-8. OCLC  324995633.
  6. ^ Mallik, A.; Weir, A. I. (2005). "Nerve conduction studies: essentials and pitfalls in practice". Journal of Neurology, Neurosurgery, and Psychiatry. 76 (Suppl 2): ii23–31. doi: 10.1136/jnnp.2005.069138. ISSN  0022-3050. PMC  1765692. PMID  15961865.
  7. ^ a b c d e Fisher, Morris A. (1992). "AAEM minimonograph #13: H reflexes and F waves: Physiology and clinical indications". Muscle & Nerve. 15 (11): 1223–1233. doi: 10.1002/mus.880151102. ISSN  1097-4598. PMID  1488060. S2CID  6174526.
  8. ^ Lachman, T; Shahani, B T; Young, R R (1980). "Late responses as aids to diagnosis in peripheral neuropathy". Journal of Neurology, Neurosurgery, and Psychiatry. 43 (2): 156–162. doi: 10.1136/jnnp.43.2.156. ISSN  0022-3050. PMC  490491. PMID  6244369.
  9. ^ Magladery, J. W.; McDOUGAL, D. B. (1950). "Electrophysiological studies of nerve and reflex activity in normal man. I. Identification of certain reflexes in the electromyogram and the conduction velocity of peripheral nerve fibers". Bulletin of the Johns Hopkins Hospital. 86 (5): 265–290. ISSN  0097-1383. PMID  15414383.
  10. ^ Wulff, C. H.; Gilliatt, R. W. (1979). "F waves in patients with hand wasting caused by a cervical rib and band". Muscle & Nerve. 2 (6): 452–457. doi: 10.1002/mus.880020606. ISSN  0148-639X. PMID  514311. S2CID  2423723.
  11. ^ a b Fox, J E; Hitchcock, E R (1987). "F wave size as a monitor of motor neuron excitability: the effect of deafferentation". Journal of Neurology, Neurosurgery, and Psychiatry. 50 (4): 453–459. doi: 10.1136/jnnp.50.4.453. ISSN  0022-3050. PMC  1031882. PMID  3585357.
  12. ^ Trontelj, JV (1973). A study of the F response by single fiber electromyography, in Desmedt JE (ed): New Developments in Electromyography and Clinical Neurophysiology. Basel: Karger. pp. 318–322.
  13. ^ a b c Panayiotopoulos, C. P.; Chroni, E. (1996). "F-waves in clinical neurophysiology: a review, methodological issues and overall value in peripheral neuropathies". Electroencephalography and Clinical Neurophysiology. 101 (5): 365–374. ISSN  0013-4694. PMID  8913188.
  14. ^ Sathya, G. R.; Krishnamurthy, N.; Veliath, Susheela; Arulneyam, Jayanthi; Venkatachalam, J. (2017). "F wave index: A diagnostic tool for peripheral neuropathy". The Indian Journal of Medical Research. 145 (3): 353–357. doi: 10.4103/ijmr.IJMR_1087_14 (inactive 31 January 2024). ISSN  0971-5916. PMC  5555064. PMID  28749398.{{ cite journal}}: CS1 maint: DOI inactive as of January 2024 ( link)
  15. ^ a b Kimura, Jun (2004-01-01). "Peripheral nerve conduction studies and neuromuscular junction testing". In Eisen, Andrew (ed.). Clinical Neurophysiology of Motor Neuron Diseases. Handbook of Clinical Neurophysiology. Vol. 4. Elsevier. pp. 241–270. doi: 10.1016/S1567-4231(04)04012-2. ISBN  9780444513595. Retrieved 2020-02-26.
  16. ^ Moore, Niall J.; Bhumbra, Gardave S.; Foster, Joshua D.; Beato, Marco (2015-10-07). "Synaptic Connectivity between Renshaw Cells and Motoneurons in the Recurrent Inhibitory Circuit of the Spinal Cord". The Journal of Neuroscience. 35 (40): 13673–13686. doi: 10.1523/JNEUROSCI.2541-15.2015. ISSN  0270-6474. PMC  4595620. PMID  26446220.
  17. ^ Fisher, Morris A.; Patil, Vijaya K.; Webber, Charles L. (2015). "Recurrence Quantification Analysis of F-Waves and the Evaluation of Neuropathies". Neurology Research International. 2015: 183608. doi: 10.1155/2015/183608. ISSN  2090-1852. PMC  4672360. PMID  26688754.
Retrieved from " https://en.wikipedia.org/?title=F_wave&oldid=1201887777"

Videos

Youtube | Vimeo | Bing

Websites

Google | Yahoo | Bing

Encyclopedia

Google | Yahoo | Bing

Facebook




Top Of Page

Home • Search • Translate

© CSE