Formin-binding protein 1-like is a
protein that in humans is encoded by the FNBP1Lgene.[3][4]
Function
The protein encoded by this gene binds to both
CDC42 and
N-WASP. This protein promotes CDC42-induced
actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin
cytoskeleton.
Alternative splicing results in multiple transcript variants encoding different isoforms.[4]
Clinical significance
FNBP1Lpolymorphisms, specifically the
SNP rs236330 has been associated with normally varying
intelligence differences in adults[5] and in children.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Katoh M, Katoh M (Dec 2003). "Identification and characterization of human FNBP1L gene in silico". Int J Mol Med. 13 (1): 157–62.
doi:
10.3892/ijmm.13.1.157.
PMID14654988.
Aspenström P, Richnau N, Johansson AS (2006). "The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics". Exp. Cell Res. 312 (12): 2180–94.
doi:
10.1016/j.yexcr.2006.03.013.
PMID16630611.
Formin-binding protein 1-like is a
protein that in humans is encoded by the FNBP1Lgene.[3][4]
Function
The protein encoded by this gene binds to both
CDC42 and
N-WASP. This protein promotes CDC42-induced
actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin
cytoskeleton.
Alternative splicing results in multiple transcript variants encoding different isoforms.[4]
Clinical significance
FNBP1Lpolymorphisms, specifically the
SNP rs236330 has been associated with normally varying
intelligence differences in adults[5] and in children.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Katoh M, Katoh M (Dec 2003). "Identification and characterization of human FNBP1L gene in silico". Int J Mol Med. 13 (1): 157–62.
doi:
10.3892/ijmm.13.1.157.
PMID14654988.
Aspenström P, Richnau N, Johansson AS (2006). "The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics". Exp. Cell Res. 312 (12): 2180–94.
doi:
10.1016/j.yexcr.2006.03.013.
PMID16630611.