Formin-like protein 2 is a
protein that in humans is encoded by the FMNL2gene.[5][6]
Expression
Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described.[5] The full length FMNL2 (FRL3) protein (1092 amino acids-NCBI Reference Sequence: NP_443137.2[7]) is regulated through autoinhibition, and may become activated through
Rho proteins.[8] The FMNL2 gene is expressed in multiple human tissues.[9]
Function
Formin-like protein 2 is a
formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity.[5]
Clinical significance
FMNL2 expression is considerably higher in
colorectal cancer tumors compared to normal tissue.[10]
^Katoh M, Katoh M (May 2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". Int. J. Oncol. 22 (5): 1161–8.
doi:
10.3892/ijo.22.5.1161.
PMID12684686.
^"formin-like protein 2 [Homo sapiens]"(NCBI Reference Sequence: NP_443137.2). National Center for Biotechnology Information, U.S. National Library of Medicine.
^Zhu XL, Liang L, Ding YQ (November 2008). "Overexpression of FMNL2 is closely related to metastasis of colorectal cancer". Int J Colorectal Dis. 23 (11): 1041–7.
doi:
10.1007/s00384-008-0520-2.
PMID18665374.
S2CID22119273.
Formin-like protein 2 is a
protein that in humans is encoded by the FMNL2gene.[5][6]
Expression
Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described.[5] The full length FMNL2 (FRL3) protein (1092 amino acids-NCBI Reference Sequence: NP_443137.2[7]) is regulated through autoinhibition, and may become activated through
Rho proteins.[8] The FMNL2 gene is expressed in multiple human tissues.[9]
Function
Formin-like protein 2 is a
formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity.[5]
Clinical significance
FMNL2 expression is considerably higher in
colorectal cancer tumors compared to normal tissue.[10]
^Katoh M, Katoh M (May 2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". Int. J. Oncol. 22 (5): 1161–8.
doi:
10.3892/ijo.22.5.1161.
PMID12684686.
^"formin-like protein 2 [Homo sapiens]"(NCBI Reference Sequence: NP_443137.2). National Center for Biotechnology Information, U.S. National Library of Medicine.
^Zhu XL, Liang L, Ding YQ (November 2008). "Overexpression of FMNL2 is closely related to metastasis of colorectal cancer". Int J Colorectal Dis. 23 (11): 1041–7.
doi:
10.1007/s00384-008-0520-2.
PMID18665374.
S2CID22119273.