FK962 is a compound which acts as an enhancer of
somatostatin release. It stimulates nerve growth and
neurite elongation, and has been researched in animal models for potential applications in the treatment of conditions such as
Alzheimer's disease and
retinal neuropathy.[1][2][3][4]
^Tokita K, Inoue T, Yamazaki S, Wang F, Yamaji T, Matsuoka N, Mutoh S (December 2005). "FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats". European Journal of Pharmacology. 527 (1–3): 111–120.
doi:
10.1016/j.ejphar.2005.10.022.
PMID16325809.
^McCarthy AD, Owens IJ, Bansal AT, McTighe SM, Bussey TJ, Saksida LM (March 2011). "FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease". Pharmacology, Biochemistry, and Behavior. 98 (1): 76–80.
doi:
10.1016/j.pbb.2010.11.019.
PMID21130801.
S2CID26055819.
^Kishimoto Y, Yabuta C, Shearer TR, Azuma M (August 2012). "FK962 promotes neurite elongation and regeneration of cultured rat trigeminal ganglion cells: possible involvement of GDNF". Investigative Ophthalmology & Visual Science. 53 (9): 5312–5319.
doi:
10.1167/iovs.11-8957.
PMID22714891.
^Nakajima E, Walkup RD, Shearer TR, Azuma M (January 2017). "FK962 induces neurite outgrowth in cultured monkey trigeminal ganglion cells". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie. 255 (1): 107–112.
doi:
10.1007/s00417-016-3525-5.
PMID27778122.
S2CID26043647.
FK962 is a compound which acts as an enhancer of
somatostatin release. It stimulates nerve growth and
neurite elongation, and has been researched in animal models for potential applications in the treatment of conditions such as
Alzheimer's disease and
retinal neuropathy.[1][2][3][4]
^Tokita K, Inoue T, Yamazaki S, Wang F, Yamaji T, Matsuoka N, Mutoh S (December 2005). "FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats". European Journal of Pharmacology. 527 (1–3): 111–120.
doi:
10.1016/j.ejphar.2005.10.022.
PMID16325809.
^McCarthy AD, Owens IJ, Bansal AT, McTighe SM, Bussey TJ, Saksida LM (March 2011). "FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease". Pharmacology, Biochemistry, and Behavior. 98 (1): 76–80.
doi:
10.1016/j.pbb.2010.11.019.
PMID21130801.
S2CID26055819.
^Kishimoto Y, Yabuta C, Shearer TR, Azuma M (August 2012). "FK962 promotes neurite elongation and regeneration of cultured rat trigeminal ganglion cells: possible involvement of GDNF". Investigative Ophthalmology & Visual Science. 53 (9): 5312–5319.
doi:
10.1167/iovs.11-8957.
PMID22714891.
^Nakajima E, Walkup RD, Shearer TR, Azuma M (January 2017). "FK962 induces neurite outgrowth in cultured monkey trigeminal ganglion cells". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie. 255 (1): 107–112.
doi:
10.1007/s00417-016-3525-5.
PMID27778122.
S2CID26043647.