In molecular biology, the FEZ-like protein family is a family of
eukaryoticproteins thought to be involved in
axonal outgrowth and
fasciculation.[1] The
N-terminal regions of these
sequences are less
conserved than the
C-terminal regions, and are highly acidic.[1] The Caenorhabditis eleganshomologue, UNC-76, may play structural and
signalling roles in the control of axonal extension and adhesion (particularly in the presence of adjacent neuronal cells[2]) and these roles have also been postulated for other FEZ family
proteins.[1] Certain homologues have been definitively found to
interact with the N-terminal variable region (V1) of
PKC-zeta, and this interaction causes
cytoplasmic translocation of the FEZ family protein in
mammalianneuronalcells.[2] The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta.[2] The members of this family are predicted to form
coiled-coilstructures[2][3] which may
interact with members of the
RhoA family of signalling
proteins,[2] but are not thought to contain other characteristic
protein motifs.[3] Certain members of this family are
expressed almost exclusively in the
brain, whereas others (such as
FEZ2) are
expressed in other
tissues, and are thought to perform similar but unknown functions in these
tissues.[3]
In molecular biology, the FEZ-like protein family is a family of
eukaryoticproteins thought to be involved in
axonal outgrowth and
fasciculation.[1] The
N-terminal regions of these
sequences are less
conserved than the
C-terminal regions, and are highly acidic.[1] The Caenorhabditis eleganshomologue, UNC-76, may play structural and
signalling roles in the control of axonal extension and adhesion (particularly in the presence of adjacent neuronal cells[2]) and these roles have also been postulated for other FEZ family
proteins.[1] Certain homologues have been definitively found to
interact with the N-terminal variable region (V1) of
PKC-zeta, and this interaction causes
cytoplasmic translocation of the FEZ family protein in
mammalianneuronalcells.[2] The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta.[2] The members of this family are predicted to form
coiled-coilstructures[2][3] which may
interact with members of the
RhoA family of signalling
proteins,[2] but are not thought to contain other characteristic
protein motifs.[3] Certain members of this family are
expressed almost exclusively in the
brain, whereas others (such as
FEZ2) are
expressed in other
tissues, and are thought to perform similar but unknown functions in these
tissues.[3]