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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | FBXO40, FBX40, F-box protein 40 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 609107; MGI: 2443753; HomoloGene: 9459; GeneCards: FBXO40; OMA: FBXO40 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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F-box protein 40 is a protein that in humans is encoded by the FBXO40 gene. Fbxo40 induces ubiquitination of IRS1, thus limiting activity of IGF1 signaling (Shi et al, 2011). [5] [6]
Members of the F-box protein family, such as FBXO40, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [7]
Fbxo40 in particular engages a unique substrate, IRS1, which is a protein in the IGF1 signaling pathway. In this way, Fbxo40 causes ubiquitination and degradation of IRS1, blocking further signaling downstream of the IGF1 receptor. [5]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163833 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047746 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Shi J, Luo L, Eash J, Ibebunjo C, Glass DJ (November 2011). "The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling". Dev Cell. 21 (5): 835–47. doi: 10.1016/j.devcel.2011.09.011. PMID 22033112.
- ^ "Entrez Gene: F-box protein 40". Retrieved 2017-11-24.
- ^ Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW (November 2004). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes & Development. 18 (21): 2573–80. doi: 10.1101/gad.1255304. PMC 525538. PMID 15520277.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it. |
| FBXO40 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | FBXO40, FBX40, F-box protein 40 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 609107; MGI: 2443753; HomoloGene: 9459; GeneCards: FBXO40; OMA: FBXO40 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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F-box protein 40 is a protein that in humans is encoded by the FBXO40 gene. Fbxo40 induces ubiquitination of IRS1, thus limiting activity of IGF1 signaling (Shi et al, 2011). [5] [6]
Members of the F-box protein family, such as FBXO40, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [7]
Fbxo40 in particular engages a unique substrate, IRS1, which is a protein in the IGF1 signaling pathway. In this way, Fbxo40 causes ubiquitination and degradation of IRS1, blocking further signaling downstream of the IGF1 receptor. [5]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163833 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047746 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Shi J, Luo L, Eash J, Ibebunjo C, Glass DJ (November 2011). "The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling". Dev Cell. 21 (5): 835–47. doi: 10.1016/j.devcel.2011.09.011. PMID 22033112.
- ^ "Entrez Gene: F-box protein 40". Retrieved 2017-11-24.
- ^ Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW (November 2004). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes & Development. 18 (21): 2573–80. doi: 10.1101/gad.1255304. PMC 525538. PMID 15520277.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
| This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it. |