Evasin-4 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Organism | |||||||
Symbol | Eva1 | ||||||
UniProt | P0C8E9 | ||||||
|
Evasins are a family of salivary proteins produced in parasitic ticks which are capable of shutting off the first steps of an immune response brought about by chemokines. [1] These proteins are injected into a tick's host to prevent a painful inflammation that might otherwise alert the host to the tick's presence. As chemokines have been implicated in a number of inflammatory diseases including atherosclerosis, asthma, rheumatoid arthritis, and cancer, chemokine-binding proteins such as evasins are being researched to assess their therapeutic potential as chemokine-targeting antagonists. [2]
The same term is also used to refer to other proteins.
The brown dog tick evasin-4 binds to CCL5 and CCL11, but appears to neutralize even more chemokines. [3] It has an Ig-fold domain. Other evasins in this organism include Evasin-1 ( P0C8E7) and Evasin-3 ( P0C8E8). [1]
Evasin is also used to refer to any viral proteins used for the evasion of the immune responses. This usage is rare. [4]
The term is also used to refer to "Endogenous VASopeptidase INhibitors" ( Q9PW56), a kind of endogenous brain protein found in snakes.
Evasin-4 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Organism | |||||||
Symbol | Eva1 | ||||||
UniProt | P0C8E9 | ||||||
|
Evasins are a family of salivary proteins produced in parasitic ticks which are capable of shutting off the first steps of an immune response brought about by chemokines. [1] These proteins are injected into a tick's host to prevent a painful inflammation that might otherwise alert the host to the tick's presence. As chemokines have been implicated in a number of inflammatory diseases including atherosclerosis, asthma, rheumatoid arthritis, and cancer, chemokine-binding proteins such as evasins are being researched to assess their therapeutic potential as chemokine-targeting antagonists. [2]
The same term is also used to refer to other proteins.
The brown dog tick evasin-4 binds to CCL5 and CCL11, but appears to neutralize even more chemokines. [3] It has an Ig-fold domain. Other evasins in this organism include Evasin-1 ( P0C8E7) and Evasin-3 ( P0C8E8). [1]
Evasin is also used to refer to any viral proteins used for the evasion of the immune responses. This usage is rare. [4]
The term is also used to refer to "Endogenous VASopeptidase INhibitors" ( Q9PW56), a kind of endogenous brain protein found in snakes.