| Human herpesvirus 1 small nucleolar RNA | |
|---|---|
 Sequence concservation of v-snoRNA1 | |
| Identifiers | |
| Symbol | v-snoRNA1 |
| Rfam | RF01516 |
| Other data | |
| RNA type | snoRNA |
| PDB structures | PDBe |
V-snoRNA1 is a box CD- snoRNA[ clarification needed] identified in B lymphocytes infected with the EpsteinâBarr virus (human herpesvirus 4 (HHV-4)). [1] This snoRNA is the first known example of a snoRNA expressed from a viral genome. [2] It is homologous to eukaryotic snoRNAs because it contains the C and D boxes sequence motifs[ clarification needed] but lacks a terminal stem-loop structure. The nucleolar localization of v-snoRNA1 was determined by in situ hybridization. V-snoRNA1 can form into a ribonucleoprotein complex (snoRNP) as co-immunoprecipitation (CoIP) assays showed that this snoRNA interacts with the snoRNA core proteins, fibrillarin, Nop56, Nop58.[ clarification needed] It has also been proposed that this snoRNA may act as a miRNA-like precursor that is processed into 24-nucleotide-sized RNA fragments that target the 3' UTR[ clarification needed] of viral DNA polymerase mRNA. [1]
See also
References
- ^ a b Hutzinger R, Feederle R, Mrazek J, Schiefermeier N, Balwierz PJ, Zavolan M, Polacek N, Delecluse HJ, HĂźttenhofer A (August 2009). Cullen BR (ed.). "Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome". PLOS Pathogens. 5 (8): e1000547. doi: 10.1371/journal.ppat.1000547. PMC 2718842. PMID 19680535.
- ^ Gardner PP, Bateman A, Poole AM (2010). "SnoPatrol: how many snoRNA genes are there?". Journal of Biology. 9 (1): 4. doi: 10.1186/jbiol211. PMC 2871523. PMID 20122292.
External links
| Human herpesvirus 1 small nucleolar RNA | |
|---|---|
|
Sequence concservation of v-snoRNA1 | |
| Identifiers | |
| Symbol | v-snoRNA1 |
| Rfam | RF01516 |
| Other data | |
| RNA type | snoRNA |
| PDB structures | PDBe |
V-snoRNA1 is a box CD- snoRNA[ clarification needed] identified in B lymphocytes infected with the EpsteinâBarr virus (human herpesvirus 4 (HHV-4)). [1] This snoRNA is the first known example of a snoRNA expressed from a viral genome. [2] It is homologous to eukaryotic snoRNAs because it contains the C and D boxes sequence motifs[ clarification needed] but lacks a terminal stem-loop structure. The nucleolar localization of v-snoRNA1 was determined by in situ hybridization. V-snoRNA1 can form into a ribonucleoprotein complex (snoRNP) as co-immunoprecipitation (CoIP) assays showed that this snoRNA interacts with the snoRNA core proteins, fibrillarin, Nop56, Nop58.[ clarification needed] It has also been proposed that this snoRNA may act as a miRNA-like precursor that is processed into 24-nucleotide-sized RNA fragments that target the 3' UTR[ clarification needed] of viral DNA polymerase mRNA. [1]
See also
References
- ^ a b Hutzinger R, Feederle R, Mrazek J, Schiefermeier N, Balwierz PJ, Zavolan M, Polacek N, Delecluse HJ, HĂźttenhofer A (August 2009). Cullen BR (ed.). "Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome". PLOS Pathogens. 5 (8): e1000547. doi: 10.1371/journal.ppat.1000547. PMC 2718842. PMID 19680535.
- ^ Gardner PP, Bateman A, Poole AM (2010). "SnoPatrol: how many snoRNA genes are there?". Journal of Biology. 9 (1): 4. doi: 10.1186/jbiol211. PMC 2871523. PMID 20122292.