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Clinical data | |
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ATCvet code | |
Identifiers | |
CAS Number | |
PubChem CID | |
UNII | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C107H138Cl2N26O31 |
Molar mass | 2355.33 g·mol−1 |
Enramycin (also known as enduracidin) is a polypeptide antibiotic produced by Streptomyces fungicidus. Enramycin is widely used as a feed additive for pigs and chickens to prevent necrotic enteritis induced by Gram-positive gut pathogens. [1]
Enramycin acts as an inhibitor of the enzyme MurG, which is essential for cell wall biosynthesis in Gram-positive bacteria. MurG catalyzes the transglycosylation reaction in the last step of peptidoglycan biosynthesis. Inhibiting this step greatly compromises cell wall integrity leading to cell lysis. [2]
Enramycin has been found to be very effective against Gram-positive gut pathogens, most notably, Clostridium perfringens; a leading cause of necrotic enteritis.[ citation needed] The following represents MIC data for a couple of veterinary pathogens. [3]
Standard grade enramycin is composed of two main components called enramycin A and enramycin B. These two components are routinely used as analytical reference standards; however, their activity as individual compounds does not appear to be widely studied or characterized. [4]
![]() | |
Clinical data | |
---|---|
ATCvet code | |
Identifiers | |
CAS Number | |
PubChem CID | |
UNII | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C107H138Cl2N26O31 |
Molar mass | 2355.33 g·mol−1 |
Enramycin (also known as enduracidin) is a polypeptide antibiotic produced by Streptomyces fungicidus. Enramycin is widely used as a feed additive for pigs and chickens to prevent necrotic enteritis induced by Gram-positive gut pathogens. [1]
Enramycin acts as an inhibitor of the enzyme MurG, which is essential for cell wall biosynthesis in Gram-positive bacteria. MurG catalyzes the transglycosylation reaction in the last step of peptidoglycan biosynthesis. Inhibiting this step greatly compromises cell wall integrity leading to cell lysis. [2]
Enramycin has been found to be very effective against Gram-positive gut pathogens, most notably, Clostridium perfringens; a leading cause of necrotic enteritis.[ citation needed] The following represents MIC data for a couple of veterinary pathogens. [3]
Standard grade enramycin is composed of two main components called enramycin A and enramycin B. These two components are routinely used as analytical reference standards; however, their activity as individual compounds does not appear to be widely studied or characterized. [4]