ELMO DOMAIN CONTAINING 2

ELMOD2
Identifiers
Aliases	ELMOD2, 9830169G11Rik, ELMO domain containing 2
External IDs	OMIM: 610196; MGI: 2445165; HomoloGene: 16662; GeneCards: ELMOD2; OMA: ELMOD2 - orthologs
Gene location ( Human)
Chr.	Chromosome 4 (human)
End	140,553,770 bp
Gene location ( Mouse)
Chr.	Chromosome 8 (mouse)
End	84,059,115 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; mucosa of ileum; ; renal medulla; ; lateral nuclear group of thalamus; ; spinal ganglia; ; cardia; ; trigeminal ganglion; ; mucosa of paranasal sinus; ; jejunal mucosa; ; nasal epithelium;
	Top expressed in
	primary oocyte; ; otic vesicle; ; secondary oocyte; ; zygote; ; otolith organ; ; utricle; ; Epithelium of choroid plexus; ; hand; ; retinal pigment epithelium; ; medullary collecting duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activator activity;
Cellular component	membrane;
Biological process	defense response to virus; regulation of defense response to virus; positive regulation of GTPase activity;
	Sources: Amigo / QuickGO
Orthologs
	255520
	244548
	ENSG00000179387
	ENSMUSG00000035151
	Q8IZ81
	Q8BGF6
	NM_153702
	NM_001170691; NM_178736
	NP_714913
	NP_001164162; NP_848851
	Wikidata
View/Edit Human	View/Edit Mouse

ELMO domain containing 2 is a protein that in humans is encoded by the ELMOD2 gene. ^[5]

Function

This gene encodes one of six engulfment and motility (ELMO) domain-containing proteins. This gene is thought to play a role in antiviral responses. Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179387 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035151 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ELMO domain containing 2". Retrieved 2016-08-29.

Hodgson U, Pulkkinen V, Dixon M, Peyrard-Janvid M, Rehn M, Lahermo P, Ollikainen V, Salmenkivi K, Kinnula V, Kere J, Tukiainen P, Laitinen T (2006). "ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis". Am. J. Hum. Genet. 79 (1): 149–54. doi: 10.1086/504639. PMC 1474126. PMID 16773575.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179387 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035151 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ELMO domain containing 2". Retrieved 2016-08-29.

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