ELAV-like protein 3 is a
protein that in humans is encoded by the ELAVL3gene.[5][6]
A member of the ELAVL protein family, ELAV-like 3 is a
neural-specific
RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu
antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum
antibody present in sera from patients with paraneoplastic
encephalomyelitis and sensory
neuronopathy (
PEM/PSN) suggests it has a role in
neurogenesis. Two alternatively spliced
transcript variants encoding distinct
isoforms have been found for this gene.[6]
Behrends U, Jandl T, Golbeck A, et al. (2002). "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library". Int. J. Cancer. 100 (6): 669–77.
doi:
10.1002/ijc.10550.
PMID12209604.
S2CID35369661.
Sakai K, Kitagawa Y, Hirose G (1999). "Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA". Biochem. Biophys. Res. Commun. 256 (2): 263–8.
doi:
10.1006/bbrc.1999.0282.
PMID10079173.
Sakai K, Gofuku M, Kitagawa Y, et al. (1994). "A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma". Biochem. Biophys. Res. Commun. 199 (3): 1200–8.
doi:
10.1006/bbrc.1994.1358.
PMID7511893.
ELAV-like protein 3 is a
protein that in humans is encoded by the ELAVL3gene.[5][6]
A member of the ELAVL protein family, ELAV-like 3 is a
neural-specific
RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu
antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum
antibody present in sera from patients with paraneoplastic
encephalomyelitis and sensory
neuronopathy (
PEM/PSN) suggests it has a role in
neurogenesis. Two alternatively spliced
transcript variants encoding distinct
isoforms have been found for this gene.[6]
Behrends U, Jandl T, Golbeck A, et al. (2002). "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library". Int. J. Cancer. 100 (6): 669–77.
doi:
10.1002/ijc.10550.
PMID12209604.
S2CID35369661.
Sakai K, Kitagawa Y, Hirose G (1999). "Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA". Biochem. Biophys. Res. Commun. 256 (2): 263–8.
doi:
10.1006/bbrc.1999.0282.
PMID10079173.
Sakai K, Gofuku M, Kitagawa Y, et al. (1994). "A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma". Biochem. Biophys. Res. Commun. 199 (3): 1200–8.
doi:
10.1006/bbrc.1994.1358.
PMID7511893.