Irene Palaiologina or Palaeologina (Greek: Ειρήνη Παλαιολογίνα) may refer to:

• Irene Palaiologina, Empress of Bulgaria, daughter of Michael VIII Palaiologos, Empress-consort of Bulgaria in 1279–80
• Irene Palaiologina, illegitimate daughter of Andronikos II Palaiologos, wife of John II Doukas of Epirus
• Irene Palaiologina of Trebizond, illegitimate daughter of Andronikos III Palaiologos, reigning Empress of Trebizond in 1340–41
• Irene Palaiologina (Byzantine empress), Empress-consort of Matthew Kantakouzenos
• Maria-Irene Palaiologina
• Irene Palaiologina, daughter of Helena Kantakouzene and wife of Khalil of Bithynia, son of Orhan I with Helena's sister, Theodora Kantakouzenos.
• Irene Palaiologina, mother of Theodora Raoulaina
• Irene Palaiologina, daughter of Lazar Branković and Helena Palaiologina

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