Edward Slater | |
---|---|
![]() photo by Piet Borst | |
Born | [1] | 16 January 1917
Died | 26 March 2016[1]
Painswick, UK | (aged 99)
Alma mater |
|
Awards |
|
Scientific career | |
Fields | |
Institutions | |
Doctoral advisor | David Keilin |
Notable students | Piet Borst |
Edward Charles Slater FRS FAA (16 January 1917 – 26 March 2016), also known as Bill Slater, was an Australian biochemist who spent most of his career at the University of Amsterdam.
Slater was raised in Australia. He received a training in biochemistry at the Ormond College of the University of Melbourne. [1] [2] [3] In 1946, he moved to Cambridge, where he earned his PhD under the supervision of David Keilin. [2] [3]
In 1955, Slater joined the medical faculty of the University of Amsterdam, where he remained until retiring in 1985. [1] [2] [3] He is recognised for his contributions to the development of Dutch biochemistry. [3] [4]
Slater managed the journal Biochimica et Biophysica Acta, turning it into one of the most influential publications in the field. [3] [4] He wrote a history of the journal, Biochimica et biophysica acta: the story of a biochemical journal, which was published in 1986. [1]
He served as the president of the International Union of Biochemistry and Molecular Biology from 1988 until 1991. [5]
Slater made contributions to the identification and understanding of the physiological role of the components of the respiratory chain, especially of the various cytochrome b complexes, iron–sulfur proteins and other iron-containing substances. He showed that the binding of certain inhibitors of oxidative phosphorylation acting at different sites ( antimycin on electron transport, oligomycin on the coupling between electron transport and oxidative phosphorylation, and aurovertin in the ATP-synthesising enzyme) can be positively cooperative, and that the degree of cooperativity depends on the state of the mitochondrial membrane. He also demonstrated negative cooperative binding of a ligand to an enzyme ( nicotinamide adenine dinucleotide to glyceraldehyde phosphate dehydrogenase), which has implications for the mechanisms of cooperative binding generally. [6]
In 1964, Slater became a member of the Royal Netherlands Academy of Arts and Sciences. [1] He was elected a Fellow of the Royal Society (FRS) in 1975. [6] [7]
In 1984, he was appointed a Knight in the Order of the Netherlands Lion, and in 1985 he was elected a Corresponding Fellow of the Australian Academy of Science. [5]
He was awarded honorary degrees by the University of Southampton (1993) and the University of Bari (1998). [1]
{{
cite web}}
: CS1 maint: bot: original URL status unknown (
link), "Intellectual property rights"
Edward Slater | |
---|---|
![]() photo by Piet Borst | |
Born | [1] | 16 January 1917
Died | 26 March 2016[1]
Painswick, UK | (aged 99)
Alma mater |
|
Awards |
|
Scientific career | |
Fields | |
Institutions | |
Doctoral advisor | David Keilin |
Notable students | Piet Borst |
Edward Charles Slater FRS FAA (16 January 1917 – 26 March 2016), also known as Bill Slater, was an Australian biochemist who spent most of his career at the University of Amsterdam.
Slater was raised in Australia. He received a training in biochemistry at the Ormond College of the University of Melbourne. [1] [2] [3] In 1946, he moved to Cambridge, where he earned his PhD under the supervision of David Keilin. [2] [3]
In 1955, Slater joined the medical faculty of the University of Amsterdam, where he remained until retiring in 1985. [1] [2] [3] He is recognised for his contributions to the development of Dutch biochemistry. [3] [4]
Slater managed the journal Biochimica et Biophysica Acta, turning it into one of the most influential publications in the field. [3] [4] He wrote a history of the journal, Biochimica et biophysica acta: the story of a biochemical journal, which was published in 1986. [1]
He served as the president of the International Union of Biochemistry and Molecular Biology from 1988 until 1991. [5]
Slater made contributions to the identification and understanding of the physiological role of the components of the respiratory chain, especially of the various cytochrome b complexes, iron–sulfur proteins and other iron-containing substances. He showed that the binding of certain inhibitors of oxidative phosphorylation acting at different sites ( antimycin on electron transport, oligomycin on the coupling between electron transport and oxidative phosphorylation, and aurovertin in the ATP-synthesising enzyme) can be positively cooperative, and that the degree of cooperativity depends on the state of the mitochondrial membrane. He also demonstrated negative cooperative binding of a ligand to an enzyme ( nicotinamide adenine dinucleotide to glyceraldehyde phosphate dehydrogenase), which has implications for the mechanisms of cooperative binding generally. [6]
In 1964, Slater became a member of the Royal Netherlands Academy of Arts and Sciences. [1] He was elected a Fellow of the Royal Society (FRS) in 1975. [6] [7]
In 1984, he was appointed a Knight in the Order of the Netherlands Lion, and in 1985 he was elected a Corresponding Fellow of the Australian Academy of Science. [5]
He was awarded honorary degrees by the University of Southampton (1993) and the University of Bari (1998). [1]
{{
cite web}}
: CS1 maint: bot: original URL status unknown (
link), "Intellectual property rights"