ELKS/RAB6-interacting/CAST family member 1 is a
protein that in humans is encoded by the ERC1gene.[5][6][7] The name ELKS is derived from "protein rich in the
amino acidsE,
L,
K and
S"[8]
The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13). Multiple transcript variants encoding different isoforms have been found for this gene.[7] ELKS has been reported to direct vesicles with
RAB6A to
melanosomes.[8]
Nakata T, Yokota T, Emi M, Minami S (2002). "Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma". Genes Chromosomes Cancer. 35 (1): 30–7.
doi:
10.1002/gcc.10095.
PMID12203787.
S2CID21891794.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92.
doi:
10.1038/nbt1240.
PMID16964243.
S2CID14294292.
ELKS/RAB6-interacting/CAST family member 1 is a
protein that in humans is encoded by the ERC1gene.[5][6][7] The name ELKS is derived from "protein rich in the
amino acidsE,
L,
K and
S"[8]
The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13). Multiple transcript variants encoding different isoforms have been found for this gene.[7] ELKS has been reported to direct vesicles with
RAB6A to
melanosomes.[8]
Nakata T, Yokota T, Emi M, Minami S (2002). "Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma". Genes Chromosomes Cancer. 35 (1): 30–7.
doi:
10.1002/gcc.10095.
PMID12203787.
S2CID21891794.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92.
doi:
10.1038/nbt1240.
PMID16964243.
S2CID14294292.