From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 4E transporter is a
protein that in humans is encoded by the EIF4ENIF1
gene .
[5]
[6]
The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic;its own nuclear import is regulated by a nuclear localization signal and nuclear export signals.
[6]
Interactions
EIF4ENIF1 has been shown to
interact with
EIF4E .
[5]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000184708 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000020454 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Dostie J, Ferraiuolo M, Pause A, Adam SA, Sonenberg N (Aug 2000).
"A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E" . EMBO J . 19 (12): 3142–56.
doi :
10.1093/emboj/19.12.3142 .
PMC
203362 .
PMID
10856257 .
^
a
b
"Entrez Gene: EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1" .
Further reading
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Warner DR, Roberts EA, Greene RM, Pisano MM (2004). "Identification of novel Smad binding proteins". Biochem. Biophys. Res. Commun . 312 (4): 1185–90.
doi :
10.1016/j.bbrc.2003.11.049 .
PMID
14651998 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Ballif BA, Villén J, Beausoleil SA, et al. (2005).
"Phosphoproteomic analysis of the developing mouse brain" . Mol. Cell. Proteomics . 3 (11): 1093–101.
doi :
10.1074/mcp.M400085-MCP200 .
PMID
15345747 .
Collins JE, Wright CL, Edwards CA, et al. (2005).
"A genome annotation-driven approach to cloning the human ORFeome" . Genome Biol . 5 (10): R84.
doi :
10.1186/gb-2004-5-10-r84 .
PMC
545604 .
PMID
15461802 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Andrei MA, Ingelfinger D, Heintzmann R, et al. (2005).
"A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies" . RNA . 11 (5): 717–27.
doi :
10.1261/rna.2340405 .
PMC
1370757 .
PMID
15840819 .
Ferraiuolo MA, Basak S, Dostie J, et al. (2005).
"A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay" . J. Cell Biol . 170 (6): 913–24.
doi :
10.1083/jcb.200504039 .
PMC
2171455 .
PMID
16157702 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Wichroski MJ, Robb GB, Rana TM (2006).
"Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies" . PLOS Pathog . 2 (5): e41.
doi :
10.1371/journal.ppat.0020041 .
PMC
1458959 .
PMID
16699599 .
Lim J, Hao T, Shaw C, et al. (2006).
"A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14.
doi :
10.1016/j.cell.2006.03.032 .
PMID
16713569 .
Denoeud F, Kapranov P, Ucla C, et al. (2007).
"Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions" . Genome Res . 17 (6): 746–59.
doi :
10.1101/gr.5660607 .
PMC
1891335 .
PMID
17567994 .