Protein argonaute-2 is a
protein that in humans is encoded by the EIF2C2gene.[5][6][7]
This gene encodes a member of the
Argonaute family of proteins which play a role in
RNA interference. The encoded protein is highly basic, and contains a
PAZ domain and a
PIWI domain. It may interact with
Dicer1 and play a role in short-interfering-RNA-mediated gene silencing.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Koesters R, Adams V, Betts D, Moos R, Schmid M, Siermann A, Hassam S, Weitz S, Lichter P, Heitz PU, von Knebel Doeberitz M, Briner J (Dec 1999). "Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression". Genomics. 61 (2): 210–8.
doi:
10.1006/geno.1999.5951.
PMID10534406.
S2CID24461432.
^Sasaki T, Shiohama A, Minoshima S, Shimizu N (Aug 2003). "Identification of eight members of the Argonaute family in the human genome small star, filled". Genomics. 82 (3): 323–30.
doi:
10.1016/S0888-7543(03)00129-0.
PMID12906857.
^Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K, Warren ST (February 2004). "Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway". Nat. Neurosci. 7 (2): 113–7.
doi:
10.1038/nn1174.
PMID14703574.
S2CID1146182.
^Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (October 2007). "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. Struct. Mol. Biol. 14 (10): 897–903.
doi:
10.1038/nsmb1302.
PMID17891150.
S2CID8136380.
Rivas FV, Tolia NH, Song JJ, et al. (2005). "Purified Argonaute2 and an siRNA form recombinant human RISC". Nat. Struct. Mol. Biol. 12 (4): 340–9.
doi:
10.1038/nsmb918.
PMID15800637.
S2CID2021813.
Sen GL, Blau HM (2005). "Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies". Nat. Cell Biol. 7 (6): 633–6.
doi:
10.1038/ncb1265.
PMID15908945.
S2CID6085169.
Protein argonaute-2 is a
protein that in humans is encoded by the EIF2C2gene.[5][6][7]
This gene encodes a member of the
Argonaute family of proteins which play a role in
RNA interference. The encoded protein is highly basic, and contains a
PAZ domain and a
PIWI domain. It may interact with
Dicer1 and play a role in short-interfering-RNA-mediated gene silencing.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Koesters R, Adams V, Betts D, Moos R, Schmid M, Siermann A, Hassam S, Weitz S, Lichter P, Heitz PU, von Knebel Doeberitz M, Briner J (Dec 1999). "Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression". Genomics. 61 (2): 210–8.
doi:
10.1006/geno.1999.5951.
PMID10534406.
S2CID24461432.
^Sasaki T, Shiohama A, Minoshima S, Shimizu N (Aug 2003). "Identification of eight members of the Argonaute family in the human genome small star, filled". Genomics. 82 (3): 323–30.
doi:
10.1016/S0888-7543(03)00129-0.
PMID12906857.
^Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K, Warren ST (February 2004). "Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway". Nat. Neurosci. 7 (2): 113–7.
doi:
10.1038/nn1174.
PMID14703574.
S2CID1146182.
^Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (October 2007). "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. Struct. Mol. Biol. 14 (10): 897–903.
doi:
10.1038/nsmb1302.
PMID17891150.
S2CID8136380.
Rivas FV, Tolia NH, Song JJ, et al. (2005). "Purified Argonaute2 and an siRNA form recombinant human RISC". Nat. Struct. Mol. Biol. 12 (4): 340–9.
doi:
10.1038/nsmb918.
PMID15800637.
S2CID2021813.
Sen GL, Blau HM (2005). "Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies". Nat. Cell Biol. 7 (6): 633–6.
doi:
10.1038/ncb1265.
PMID15908945.
S2CID6085169.