Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial is an
enzyme that in humans is encoded by the ECH1gene.[5][6]
This gene encodes a member of the hydratase/
isomerase superfamily. The gene product shows high sequence similarity to
enoyl-CoA hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, Δ3,5-Δ2,4-dienoyl-CoA isomerase, contains a
C-terminal peroxisomal targeting sequence and localizes to
peroxisomes. The rat
ortholog, which localizes to the matrix of both the peroxisome and
mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.[6]
Overview of all the structural information available in the
PDB for
UniProt: Q13011 (Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial) at the
PDBe-KB.
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial is an
enzyme that in humans is encoded by the ECH1gene.[5][6]
This gene encodes a member of the hydratase/
isomerase superfamily. The gene product shows high sequence similarity to
enoyl-CoA hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, Δ3,5-Δ2,4-dienoyl-CoA isomerase, contains a
C-terminal peroxisomal targeting sequence and localizes to
peroxisomes. The rat
ortholog, which localizes to the matrix of both the peroxisome and
mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.[6]
Overview of all the structural information available in the
PDB for
UniProt: Q13011 (Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial) at the
PDBe-KB.