 | Draft article not currently submitted for review.
This is a draft Articles for creation (AfC) submission. It is not currently pending review. While there are no deadlines, abandoned drafts may be deleted after six months. To edit the draft click on the "Edit" tab at the top of the window. To be accepted, a draft should:
It is strongly discouraged to write about yourself, your business or employer. If you do so, you must declare it. Where to get help
How to improve a draft
You can also browse Wikipedia:Featured articles and Wikipedia:Good articles to find examples of Wikipedia's best writing on topics similar to your proposed article. Improving your odds of a speedy review To improve your odds of a faster review, tag your draft with relevant WikiProject tags using the button below. This will let reviewers know a new draft has been submitted in their area of interest. For instance, if you wrote about a female astronomer, you would want to add the Biography, Astronomy, and Women scientists tags. Editor resources
Last edited by
Keith D (
talk |
contribs) 5 months ago. (
Update) |
Septo-hippocampal system is a major cholinergic system in human brain.
Anatomy
The topography of septo-hippocampal system has been studied with different techniques such as septal, fimbria-fornix or hippocampal lesions and axonal tracing methods. The septo-hippocampal system consists of the medial septum (MS) and the hippocampus (Hipp), which are connected via the fimbria-fornix. The MS projects into the Hipp almost entirely ipsilaterally, while the Hipp projects into the MS directly via the fimbria-fornix and indirectly via the lateral septum (LS). The major hippocampal subregions, CA1, CA3, and the dentate gyrus (DG), have different anatomical relationships with the MS. Each of these subregions receives ipsilateral projections from the MS, but only CA1 and CA3 project to the cholinergic and noncholinergic neurons in the MS. [1]
Function
Septo-hippocampal pathway (SH) is a central cholinergic pathway although it also involves other neuropeptides and neurotransmitters namely Gamma-aminobutyric acid (GABA). [2] In addition, the decrease of cholinergic markers while aging and dementia suggests a relation between the cognitive function and this cholinergic system. The projection of SH plays plays an important role in maintaining virous kinds of electrical activities in the hippocampus, such as theta rhythm, which is related to the performance of spatial memory tasks. Moreover, the anatomical connection of the medial septum and hippocampus via the fimbria-fornix suggests its importance in aquiring and using spatial memory. [3]
References
- ^ Okada, Kana; Okaichi, Hiroshige (June 2010). "Functional cooperation between the hippocampal subregions and the medial septum in unreinforced and reinforced spatial memory tasks". Behavioural Brain Research. 209 (2): 295–304. doi: 10.1016/j.bbr.2010.02.007. ISSN 0166-4328.
- ^ Dutar, P; Bassant, M H; Senut, M C; Lamour, Y (April 1995). "The septohippocampal pathway: structure and function of a central cholinergic system". Physiological Reviews. 75 (2): 393–427. doi: 10.1152/physrev.1995.75.2.393. ISSN 0031-9333.
- ^ Okada, Kana; Okaichi, Hiroshige (2010-06-19). "Functional cooperation between the hippocampal subregions and the medial septum in unreinforced and reinforced spatial memory tasks". Behavioural Brain Research. 209 (2): 295–304. doi: 10.1016/j.bbr.2010.02.007. ISSN 0166-4328.
| Draft article not currently submitted for review.
This is a draft Articles for creation (AfC) submission. It is not currently pending review. While there are no deadlines, abandoned drafts may be deleted after six months. To edit the draft click on the "Edit" tab at the top of the window. To be accepted, a draft should:
It is strongly discouraged to write about yourself, your business or employer. If you do so, you must declare it. Where to get help
How to improve a draft
You can also browse Wikipedia:Featured articles and Wikipedia:Good articles to find examples of Wikipedia's best writing on topics similar to your proposed article. Improving your odds of a speedy review To improve your odds of a faster review, tag your draft with relevant WikiProject tags using the button below. This will let reviewers know a new draft has been submitted in their area of interest. For instance, if you wrote about a female astronomer, you would want to add the Biography, Astronomy, and Women scientists tags. Editor resources
Last edited by
Keith D (
talk |
contribs) 5 months ago. (
Update) |
Septo-hippocampal system is a major cholinergic system in human brain.
Anatomy
The topography of septo-hippocampal system has been studied with different techniques such as septal, fimbria-fornix or hippocampal lesions and axonal tracing methods. The septo-hippocampal system consists of the medial septum (MS) and the hippocampus (Hipp), which are connected via the fimbria-fornix. The MS projects into the Hipp almost entirely ipsilaterally, while the Hipp projects into the MS directly via the fimbria-fornix and indirectly via the lateral septum (LS). The major hippocampal subregions, CA1, CA3, and the dentate gyrus (DG), have different anatomical relationships with the MS. Each of these subregions receives ipsilateral projections from the MS, but only CA1 and CA3 project to the cholinergic and noncholinergic neurons in the MS. [1]
Function
Septo-hippocampal pathway (SH) is a central cholinergic pathway although it also involves other neuropeptides and neurotransmitters namely Gamma-aminobutyric acid (GABA). [2] In addition, the decrease of cholinergic markers while aging and dementia suggests a relation between the cognitive function and this cholinergic system. The projection of SH plays plays an important role in maintaining virous kinds of electrical activities in the hippocampus, such as theta rhythm, which is related to the performance of spatial memory tasks. Moreover, the anatomical connection of the medial septum and hippocampus via the fimbria-fornix suggests its importance in aquiring and using spatial memory. [3]
References
- ^ Okada, Kana; Okaichi, Hiroshige (June 2010). "Functional cooperation between the hippocampal subregions and the medial septum in unreinforced and reinforced spatial memory tasks". Behavioural Brain Research. 209 (2): 295–304. doi: 10.1016/j.bbr.2010.02.007. ISSN 0166-4328.
- ^ Dutar, P; Bassant, M H; Senut, M C; Lamour, Y (April 1995). "The septohippocampal pathway: structure and function of a central cholinergic system". Physiological Reviews. 75 (2): 393–427. doi: 10.1152/physrev.1995.75.2.393. ISSN 0031-9333.
- ^ Okada, Kana; Okaichi, Hiroshige (2010-06-19). "Functional cooperation between the hippocampal subregions and the medial septum in unreinforced and reinforced spatial memory tasks". Behavioural Brain Research. 209 (2): 295–304. doi: 10.1016/j.bbr.2010.02.007. ISSN 0166-4328.