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Names | |
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Preferred IUPAC name
[(3,5-di-tert-Butyl-4-hydroxyphenyl)methylidene]propanedinitrile | |
Other names
Tyrphostin A9; SF-6847; GCP5126; and AG-17
| |
Identifiers | |
3D model (
JSmol)
|
|
ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.162.608 |
EC Number |
|
KEGG | |
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C18H22N2O | |
Molar mass | 282.387 g·mol−1 |
Melting point | 142 °C (288 °F; 415 K) ±1° |
Hazards | |
GHS labelling: | |
![]() | |
Danger | |
H301, H311, H331 | |
P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, P501 | |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Malonoben (also known as tyrphostin A9, SF-6847, GCP5126, and AG-17) is an uncoupling agent/ protonophore. [1] [2] As of 1974 when it was discovered, it was considered the most powerful agent of this type, with a potency over 1800 times that of 2,4-dinitrophenol - the prototypical uncoupling agent - and about 3 times the effectiveness of 5-chloro-3-tert-butyl-2'-chloro-4'-nitrosalicylanilide. [3]
![]() | |
Names | |
---|---|
Preferred IUPAC name
[(3,5-di-tert-Butyl-4-hydroxyphenyl)methylidene]propanedinitrile | |
Other names
Tyrphostin A9; SF-6847; GCP5126; and AG-17
| |
Identifiers | |
3D model (
JSmol)
|
|
ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.162.608 |
EC Number |
|
KEGG | |
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C18H22N2O | |
Molar mass | 282.387 g·mol−1 |
Melting point | 142 °C (288 °F; 415 K) ±1° |
Hazards | |
GHS labelling: | |
![]() | |
Danger | |
H301, H311, H331 | |
P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, P501 | |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Malonoben (also known as tyrphostin A9, SF-6847, GCP5126, and AG-17) is an uncoupling agent/ protonophore. [1] [2] As of 1974 when it was discovered, it was considered the most powerful agent of this type, with a potency over 1800 times that of 2,4-dinitrophenol - the prototypical uncoupling agent - and about 3 times the effectiveness of 5-chloro-3-tert-butyl-2'-chloro-4'-nitrosalicylanilide. [3]