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(Redirected from Draft:Pierre Gönczy)
Full Professor
Pierre Gönczy
Pierre Gönczy in his laboratory in 2020
Born1962 (age 61–62)
Winterthur, Switzerland
Citizenship Switzerland
Academic background
Alma mater University of Geneva
Academic work
Discipline Biology
Sub-discipline Cell biology
Developmental biology
Institutions École Polytechnique Fédérale de Lausanne (EPFL)
Main interests Centriole assembly and function
Asymmetric cell division
Website https://www.epfl.ch/labs/gonczy-lab/

Pierre Gönczy (born 1962 in Winterthur, Switzerland) is a Swiss and Italian cell and developmental biologist. His research focuses on centriole biology and asymmetric cell division. He is currently professor at École Polytechnique Fédérale de Lausanne (EPFL), [1] where he directs the Laboratory of Cell and Developmental Biology. [2]

Career

Gönczy studied biology at University of Geneva and graduated in 1987 with a diploma thesis in molecular immunology at the Department of Microbiology at University of Geneva. [3] In 1995, he received a PhD for his work on developmental biology and molecular genetics from the Rockefeller University, New York City, United States. [4] [5] [6] From 1996 to 2000 Gönczy joined the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany as a postdoctoral research fellow with Anthony Hyman to work on cell biology, cell division, and early embryonic development. [7] In 2000, he became Junior Group leader at Swiss Institute for Experimental Cancer Research (ISREC) in Lausanne, Switzerland. In 2005, he was first nominated Associate Professor, and since 2009 has been a Full Professor at École Polytechnique Fédérale de Lausanne (EPFL). [1]

Research

Gönczy's research is in the realm of cell and developmental biology, focused mainly on the questions of centriole assembly and function, as well as asymmetric cell division. [8] [9] His laboratory employs notably the model organism C. elegans and human cell lines in their research. The methods they use include functional genomics, cell biology, live imaging, super-resolution microscopy, biophysical analysis, and electron cryotomography. [10] [11] [12] He spearheaded the first ever functional genomic screening of a metazoan organism, leading to the systematic discovery of the function of the compendium of genes needed to build an embryo. [7]

Distinctions

Gönczy is recipient of the EMBO Young Investigator Program Award (2000). [13] In 2005, he was elected an EMBO member. [1] [14] He was co-founder of the startup company Cenix Bioscience. [15] He was a Whitman Fellow at the Marine Biology Laboratory, Woods Hole, USA in 2015, 2017, and 2018. [16] [17] [18]

Select publications

  • Gönczy, Pierre; Echeverri, Christophe; Oegema, Karen; Coulson, Alan; Jones, Steven J. M.; Copley, Richard R.; Duperon, John; Oegema, Jeff; Brehm, Michael; Cassin, Etienne; Hannak, Eva; Kirkham, Matthew; Pichler, Silke; Flohrs, Kathrin; Goessen, Anoesjka; Leidel, Sebastian; Alleaume, Anne-Marie; Martin, Cécilie; Özlü, Nurhan; Bork, Peer; Hyman, Anthony A. (2000). "Functional genomic analysis of cell division in C. Elegans using RNAi of genes on chromosome III". Nature. 408 (6810): 331–336. Bibcode: 2000Natur.408..331G. doi: 10.1038/35042526. PMID  11099034. S2CID  4364278.
  • Colombo, K.; Grill, Stephan W.; Kimple, Randall J.; Willard, Francis S.; Siderovski, David P.; Gönczy, Pierre (2003). "Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos". Science. 300 (5627): 1957–1961. Bibcode: 2003Sci...300.1957C. doi: 10.1126/science.1084146. PMID  12750478. S2CID  46204090.
  • Leidel, Sebastian; Delattre, Marie; Cerutti, Lorenzo; Baumer, Karine; Gönczy, Pierre (2005). "SAS-6 defines a protein family required for centrosome duplication in C. Elegans and in human cells". Nature Cell Biology. 7 (2): 115–125. doi: 10.1038/ncb1220. PMID  15665853. S2CID  4634352.
  • Kitagawa, Daiju; Vakonakis, Ioannis; Olieric, Natacha; Hilbert, Manuel; Keller, Debora; Olieric, Vincent; Bortfeld, Miriam; Erat, Michèle C.; Flückiger, Isabelle; Gönczy, Pierre; Steinmetz, Michel O. (2011). "Structural Basis of the 9-Fold Symmetry of Centrioles". Cell. 144 (3): 364–375. doi: 10.1016/j.cell.2011.01.008. PMC  3089914. PMID  21277013.
  • Guichard, Paul; Hachet, Virginie; Majubu, Norbert; Neves, Aitana; Demurtas, Davide; Olieric, Natacha; Fluckiger, Isabelle; Yamada, Akinori; Kihara, Kumiko; Nishida, Yuichiro; Moriya, Shigeharu; Steinmetz, Michel O.; Hongoh, Yuichi; Gönczy, Pierre (2013). "Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry". Current Biology. 23 (17): 1620–1628. doi: 10.1016/j.cub.2013.06.061. PMID  23932403. S2CID  17329110.
  • Nievergelt, Adrian P.; Banterle, Niccolò; Andany, Santiago H.; Gönczy, Pierre; Fantner, Georg E. (2018). "High-speed photothermal off-resonance atomic force microscopy reveals assembly routes of centriolar scaffold protein SAS-6" (PDF). Nature Nanotechnology. 13 (8): 696–701. Bibcode: 2018NatNa..13..696N. doi: 10.1038/s41565-018-0149-4. PMID  29784964. S2CID  205567962.

References

  1. ^ a b c "Pierre Gönczy". people.epfl.ch. Retrieved 2020-09-15.
  2. ^ "Gönczy Lab – Cell and Developmental Biology". www.epfl.ch. Retrieved 2020-09-15.
  3. ^ Gönczy, P; Reith, W; Barras, E; Lisowska-Grospierre, B; Griscelli, C; Hadam, M R; Mach, B (1989-01-01). "Inherited immunodeficiency with a defect in a major histocompatibility complex class II promoter-binding protein differs in the chromatin structure of the HLA-DRA gene". Molecular and Cellular Biology. 9 (1): 296–302. doi: 10.1128/MCB.9.1.296. ISSN  0270-7306. PMC  362172. PMID  2467188.
  4. ^ Trelsman, Jessica; Gönczy, Pierre; Vashishtha, Malini; Harris, Esther; Desplan, Claude (1989-11-03). "A single amino acid can determine the DNA binding specificity of homeodomain proteins". Cell. 59 (3): 553–562. doi: 10.1016/0092-8674(89)90038-X. PMID  2572327. S2CID  29300056.
  5. ^ Castrillon, D. H.; Gonczy, P.; Alexander, S.; Rawson, R.; Eberhart, C. G.; Viswanathan, S.; DiNardo, S.; Wasserman, S. A. (1993-10-01). "Toward a Molecular Genetic Analysis of Spermatogenesis in Drosophila Melanogaster: Characterization of Male-Sterile Mutants Generated by Single P Element Mutagenesis". Genetics. 135 (2): 489–505. doi: 10.1093/genetics/135.2.489. ISSN  0016-6731. PMC  1205651. PMID  8244010.
  6. ^ Gonczy, P (1994-07-01). "roughex is a dose-dependent regulator of the second meiotic division during Drosophila spermatogenesis". Cell. 77 (7): 1015–1025. doi: 10.1016/0092-8674(94)90441-3. PMID  8020092. S2CID  32059039.
  7. ^ a b Gönczy, Pierre; Echeverri, Christophe; Oegema, Karen; Coulson, Alan; Jones, Steven J. M.; Copley, Richard R.; Duperon, John; Oegema, Jeff; Brehm, Michael; Cassin, Etienne; Hannak, Eva (2000-11-16). "Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III". Nature. 408 (6810): 331–336. Bibcode: 2000Natur.408..331G. doi: 10.1038/35042526. ISSN  1476-4687. PMID  11099034. S2CID  4364278.
  8. ^ Kitagawa, Daiju; Vakonakis, Ioannis; Olieric, Natacha; Hilbert, Manuel; Keller, Debora; Olieric, Vincent; Bortfeld, Miriam; Erat, Michèle C.; Flückiger, Isabelle; Gönczy, Pierre; Steinmetz, Michel O. (2011-02-04). "Structural Basis of the 9-Fold Symmetry of Centrioles". Cell. 144 (3): 364–375. doi: 10.1016/j.cell.2011.01.008. PMC  3089914. PMID  21277013.
  9. ^ Guichard, Paul; Hachet, Virginie; Majubu, Norbert; Neves, Aitana; Demurtas, Davide; Olieric, Natacha; Fluckiger, Isabelle; Yamada, Akinori; Kihara, Kumiko; Nishida, Yuichiro; Moriya, Shigeharu (2013-09-09). "Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry". Current Biology. 23 (17): 1620–1628. doi: 10.1016/j.cub.2013.06.061. PMID  23932403. S2CID  17329110.
  10. ^ Colombo, K. (2003-05-15). "Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos". Science. 300 (5627): 1957–1961. Bibcode: 2003Sci...300.1957C. doi: 10.1126/science.1084146. ISSN  0036-8075. PMID  12750478. S2CID  46204090.
  11. ^ Leidel, Sebastian; Delattre, Marie; Cerutti, Lorenzo; Baumer, Karine; Gönczy, Pierre (2005-02-23). "SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells". Nature Cell Biology. 7 (2): 115–125. doi: 10.1038/ncb1220. ISSN  1465-7392. PMID  15665853. S2CID  4634352.
  12. ^ Nievergelt, Adrian P.; Banterle, Niccolò; Andany, Santiago H.; Gönczy, Pierre; Fantner, Georg E. (2018-08-21). "High-speed photothermal off-resonance atomic force microscopy reveals assembly routes of centriolar scaffold protein SAS-6". Nature Nanotechnology. 13 (8): 696–701. Bibcode: 2018NatNa..13..696N. doi: 10.1038/s41565-018-0149-4. ISSN  1748-3387. PMID  29784964. S2CID  205567962.
  13. ^ "Pierre Gönczy - Find an EMBO Young Investigator / EMBO Installation Grantee / EMBO Global Investigator". yip-search.embo.org. Retrieved 2020-09-15.
  14. ^ Katja. "Find a Member". EMBO. Retrieved 2020-09-15.
  15. ^ "Cenix Ends Worm Work with Screen Publication". GenomeWeb. May 2005. Retrieved 2020-09-15.
  16. ^ "2015 MBL Research Awardees". www.mbl.edu. Retrieved 2020-09-15.
  17. ^ "2017 Whitman Center Research Awardees". www.mbl.edu. Retrieved 2020-09-15.
  18. ^ "2018 Whitman Center Research Awardees". www.mbl.edu. Retrieved 2020-09-15.

External links

Retrieved from " https://en.wikipedia.org/?title=Pierre_Gönczy&oldid=1169999672"
From Wikipedia, the free encyclopedia
(Redirected from Draft:Pierre Gönczy)
Full Professor
Pierre Gönczy
Pierre Gönczy in his laboratory in 2020
Born1962 (age 61–62)
Winterthur, Switzerland
Citizenship Switzerland
Academic background
Alma mater University of Geneva
Academic work
Discipline Biology
Sub-discipline Cell biology
Developmental biology
Institutions École Polytechnique Fédérale de Lausanne (EPFL)
Main interests Centriole assembly and function
Asymmetric cell division
Website https://www.epfl.ch/labs/gonczy-lab/

Pierre Gönczy (born 1962 in Winterthur, Switzerland) is a Swiss and Italian cell and developmental biologist. His research focuses on centriole biology and asymmetric cell division. He is currently professor at École Polytechnique Fédérale de Lausanne (EPFL), [1] where he directs the Laboratory of Cell and Developmental Biology. [2]

Career

Gönczy studied biology at University of Geneva and graduated in 1987 with a diploma thesis in molecular immunology at the Department of Microbiology at University of Geneva. [3] In 1995, he received a PhD for his work on developmental biology and molecular genetics from the Rockefeller University, New York City, United States. [4] [5] [6] From 1996 to 2000 Gönczy joined the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany as a postdoctoral research fellow with Anthony Hyman to work on cell biology, cell division, and early embryonic development. [7] In 2000, he became Junior Group leader at Swiss Institute for Experimental Cancer Research (ISREC) in Lausanne, Switzerland. In 2005, he was first nominated Associate Professor, and since 2009 has been a Full Professor at École Polytechnique Fédérale de Lausanne (EPFL). [1]

Research

Gönczy's research is in the realm of cell and developmental biology, focused mainly on the questions of centriole assembly and function, as well as asymmetric cell division. [8] [9] His laboratory employs notably the model organism C. elegans and human cell lines in their research. The methods they use include functional genomics, cell biology, live imaging, super-resolution microscopy, biophysical analysis, and electron cryotomography. [10] [11] [12] He spearheaded the first ever functional genomic screening of a metazoan organism, leading to the systematic discovery of the function of the compendium of genes needed to build an embryo. [7]

Distinctions

Gönczy is recipient of the EMBO Young Investigator Program Award (2000). [13] In 2005, he was elected an EMBO member. [1] [14] He was co-founder of the startup company Cenix Bioscience. [15] He was a Whitman Fellow at the Marine Biology Laboratory, Woods Hole, USA in 2015, 2017, and 2018. [16] [17] [18]

Select publications

  • Gönczy, Pierre; Echeverri, Christophe; Oegema, Karen; Coulson, Alan; Jones, Steven J. M.; Copley, Richard R.; Duperon, John; Oegema, Jeff; Brehm, Michael; Cassin, Etienne; Hannak, Eva; Kirkham, Matthew; Pichler, Silke; Flohrs, Kathrin; Goessen, Anoesjka; Leidel, Sebastian; Alleaume, Anne-Marie; Martin, Cécilie; Özlü, Nurhan; Bork, Peer; Hyman, Anthony A. (2000). "Functional genomic analysis of cell division in C. Elegans using RNAi of genes on chromosome III". Nature. 408 (6810): 331–336. Bibcode: 2000Natur.408..331G. doi: 10.1038/35042526. PMID  11099034. S2CID  4364278.
  • Colombo, K.; Grill, Stephan W.; Kimple, Randall J.; Willard, Francis S.; Siderovski, David P.; Gönczy, Pierre (2003). "Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos". Science. 300 (5627): 1957–1961. Bibcode: 2003Sci...300.1957C. doi: 10.1126/science.1084146. PMID  12750478. S2CID  46204090.
  • Leidel, Sebastian; Delattre, Marie; Cerutti, Lorenzo; Baumer, Karine; Gönczy, Pierre (2005). "SAS-6 defines a protein family required for centrosome duplication in C. Elegans and in human cells". Nature Cell Biology. 7 (2): 115–125. doi: 10.1038/ncb1220. PMID  15665853. S2CID  4634352.
  • Kitagawa, Daiju; Vakonakis, Ioannis; Olieric, Natacha; Hilbert, Manuel; Keller, Debora; Olieric, Vincent; Bortfeld, Miriam; Erat, Michèle C.; Flückiger, Isabelle; Gönczy, Pierre; Steinmetz, Michel O. (2011). "Structural Basis of the 9-Fold Symmetry of Centrioles". Cell. 144 (3): 364–375. doi: 10.1016/j.cell.2011.01.008. PMC  3089914. PMID  21277013.
  • Guichard, Paul; Hachet, Virginie; Majubu, Norbert; Neves, Aitana; Demurtas, Davide; Olieric, Natacha; Fluckiger, Isabelle; Yamada, Akinori; Kihara, Kumiko; Nishida, Yuichiro; Moriya, Shigeharu; Steinmetz, Michel O.; Hongoh, Yuichi; Gönczy, Pierre (2013). "Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry". Current Biology. 23 (17): 1620–1628. doi: 10.1016/j.cub.2013.06.061. PMID  23932403. S2CID  17329110.
  • Nievergelt, Adrian P.; Banterle, Niccolò; Andany, Santiago H.; Gönczy, Pierre; Fantner, Georg E. (2018). "High-speed photothermal off-resonance atomic force microscopy reveals assembly routes of centriolar scaffold protein SAS-6" (PDF). Nature Nanotechnology. 13 (8): 696–701. Bibcode: 2018NatNa..13..696N. doi: 10.1038/s41565-018-0149-4. PMID  29784964. S2CID  205567962.

References

  1. ^ a b c "Pierre Gönczy". people.epfl.ch. Retrieved 2020-09-15.
  2. ^ "Gönczy Lab – Cell and Developmental Biology". www.epfl.ch. Retrieved 2020-09-15.
  3. ^ Gönczy, P; Reith, W; Barras, E; Lisowska-Grospierre, B; Griscelli, C; Hadam, M R; Mach, B (1989-01-01). "Inherited immunodeficiency with a defect in a major histocompatibility complex class II promoter-binding protein differs in the chromatin structure of the HLA-DRA gene". Molecular and Cellular Biology. 9 (1): 296–302. doi: 10.1128/MCB.9.1.296. ISSN  0270-7306. PMC  362172. PMID  2467188.
  4. ^ Trelsman, Jessica; Gönczy, Pierre; Vashishtha, Malini; Harris, Esther; Desplan, Claude (1989-11-03). "A single amino acid can determine the DNA binding specificity of homeodomain proteins". Cell. 59 (3): 553–562. doi: 10.1016/0092-8674(89)90038-X. PMID  2572327. S2CID  29300056.
  5. ^ Castrillon, D. H.; Gonczy, P.; Alexander, S.; Rawson, R.; Eberhart, C. G.; Viswanathan, S.; DiNardo, S.; Wasserman, S. A. (1993-10-01). "Toward a Molecular Genetic Analysis of Spermatogenesis in Drosophila Melanogaster: Characterization of Male-Sterile Mutants Generated by Single P Element Mutagenesis". Genetics. 135 (2): 489–505. doi: 10.1093/genetics/135.2.489. ISSN  0016-6731. PMC  1205651. PMID  8244010.
  6. ^ Gonczy, P (1994-07-01). "roughex is a dose-dependent regulator of the second meiotic division during Drosophila spermatogenesis". Cell. 77 (7): 1015–1025. doi: 10.1016/0092-8674(94)90441-3. PMID  8020092. S2CID  32059039.
  7. ^ a b Gönczy, Pierre; Echeverri, Christophe; Oegema, Karen; Coulson, Alan; Jones, Steven J. M.; Copley, Richard R.; Duperon, John; Oegema, Jeff; Brehm, Michael; Cassin, Etienne; Hannak, Eva (2000-11-16). "Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III". Nature. 408 (6810): 331–336. Bibcode: 2000Natur.408..331G. doi: 10.1038/35042526. ISSN  1476-4687. PMID  11099034. S2CID  4364278.
  8. ^ Kitagawa, Daiju; Vakonakis, Ioannis; Olieric, Natacha; Hilbert, Manuel; Keller, Debora; Olieric, Vincent; Bortfeld, Miriam; Erat, Michèle C.; Flückiger, Isabelle; Gönczy, Pierre; Steinmetz, Michel O. (2011-02-04). "Structural Basis of the 9-Fold Symmetry of Centrioles". Cell. 144 (3): 364–375. doi: 10.1016/j.cell.2011.01.008. PMC  3089914. PMID  21277013.
  9. ^ Guichard, Paul; Hachet, Virginie; Majubu, Norbert; Neves, Aitana; Demurtas, Davide; Olieric, Natacha; Fluckiger, Isabelle; Yamada, Akinori; Kihara, Kumiko; Nishida, Yuichiro; Moriya, Shigeharu (2013-09-09). "Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry". Current Biology. 23 (17): 1620–1628. doi: 10.1016/j.cub.2013.06.061. PMID  23932403. S2CID  17329110.
  10. ^ Colombo, K. (2003-05-15). "Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos". Science. 300 (5627): 1957–1961. Bibcode: 2003Sci...300.1957C. doi: 10.1126/science.1084146. ISSN  0036-8075. PMID  12750478. S2CID  46204090.
  11. ^ Leidel, Sebastian; Delattre, Marie; Cerutti, Lorenzo; Baumer, Karine; Gönczy, Pierre (2005-02-23). "SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells". Nature Cell Biology. 7 (2): 115–125. doi: 10.1038/ncb1220. ISSN  1465-7392. PMID  15665853. S2CID  4634352.
  12. ^ Nievergelt, Adrian P.; Banterle, Niccolò; Andany, Santiago H.; Gönczy, Pierre; Fantner, Georg E. (2018-08-21). "High-speed photothermal off-resonance atomic force microscopy reveals assembly routes of centriolar scaffold protein SAS-6". Nature Nanotechnology. 13 (8): 696–701. Bibcode: 2018NatNa..13..696N. doi: 10.1038/s41565-018-0149-4. ISSN  1748-3387. PMID  29784964. S2CID  205567962.
  13. ^ "Pierre Gönczy - Find an EMBO Young Investigator / EMBO Installation Grantee / EMBO Global Investigator". yip-search.embo.org. Retrieved 2020-09-15.
  14. ^ Katja. "Find a Member". EMBO. Retrieved 2020-09-15.
  15. ^ "Cenix Ends Worm Work with Screen Publication". GenomeWeb. May 2005. Retrieved 2020-09-15.
  16. ^ "2015 MBL Research Awardees". www.mbl.edu. Retrieved 2020-09-15.
  17. ^ "2017 Whitman Center Research Awardees". www.mbl.edu. Retrieved 2020-09-15.
  18. ^ "2018 Whitman Center Research Awardees". www.mbl.edu. Retrieved 2020-09-15.

External links

Retrieved from " https://en.wikipedia.org/?title=Pierre_Gönczy&oldid=1169999672"

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