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Fast-spiking Parvalbumin Positive GABAergic Interneurons (sometimes refered to as PV+ interneurons) are a subset of interneurons that feature distinct fast-spiking electrophysiological properties and are typically identified based on expression of the calcium-binding protein parvalbumin [1] [2] [3]
Their morphology typically falls into either the subcategory of basket cells or chandelier cells and are commonly ensheathed in perineuronal nets, although delineation of interneuron subtypes is a developing field [4]
PV+ Interneurons play significant roles in many aspects of network activity such as feedforward inhibition, feedback inhibition, network oscillations, and regulation of plasticity [5]
This type of cells receives the greatest amount of excitatory input of any inhibitory neuron in the cortex, and they powerfully regulate local pyramidal cell network activity [6] [7]
During gamma-oscillations the metabolic demand on PV+ interneurons is similar to that observed in seizure-like events [8], suggesting that during heightened activity this cell type is prone to metabolic disruption [9] [10]
Supporting structures such as the specialized ECM structure perineuronal nets (PNNs) preferentially [11] wrap around PV+ interneurons to support their fast-spiking properties by providing a cation rich environment, reducing membrance capacitance and buffering them against metabolic stress [12] [13]
The developmental trajectory of PV+ interneurons and the supporting PNNs that wrap around them coincides with critical period opening and closure, with maturation of the PV+ interneurons and the PNNs marking the closure of the critical period. [14] [15] [16] [17]
Treatment with NMDA receptor antagonist such as ketamine, PCP, or MK-801 that disrupt the NMDAR-mediated input to PV+ Interneurons have the potential to modulate critical period plasticity [18]
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Submission declined on 10 May 2024 by
CanonNi (
talk). This submission provides insufficient
context for those unfamiliar with the subject matter. Please see the
guide to writing better articles for information on how to better format your submission.
Where to get help
How to improve a draft
You can also browse Wikipedia:Featured articles and Wikipedia:Good articles to find examples of Wikipedia's best writing on topics similar to your proposed article. Improving your odds of a speedy review To improve your odds of a faster review, tag your draft with relevant WikiProject tags using the button below. This will let reviewers know a new draft has been submitted in their area of interest. For instance, if you wrote about a female astronomer, you would want to add the Biography, Astronomy, and Women scientists tags. Editor resources
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Fast-spiking Parvalbumin Positive GABAergic Interneurons (sometimes refered to as PV+ interneurons) are a subset of interneurons that feature distinct fast-spiking electrophysiological properties and are typically identified based on expression of the calcium-binding protein parvalbumin [1] [2] [3]
Their morphology typically falls into either the subcategory of basket cells or chandelier cells and are commonly ensheathed in perineuronal nets, although delineation of interneuron subtypes is a developing field [4]
PV+ Interneurons play significant roles in many aspects of network activity such as feedforward inhibition, feedback inhibition, network oscillations, and regulation of plasticity [5]
This type of cells receives the greatest amount of excitatory input of any inhibitory neuron in the cortex, and they powerfully regulate local pyramidal cell network activity [6] [7]
During gamma-oscillations the metabolic demand on PV+ interneurons is similar to that observed in seizure-like events [8], suggesting that during heightened activity this cell type is prone to metabolic disruption [9] [10]
Supporting structures such as the specialized ECM structure perineuronal nets (PNNs) preferentially [11] wrap around PV+ interneurons to support their fast-spiking properties by providing a cation rich environment, reducing membrance capacitance and buffering them against metabolic stress [12] [13]
The developmental trajectory of PV+ interneurons and the supporting PNNs that wrap around them coincides with critical period opening and closure, with maturation of the PV+ interneurons and the PNNs marking the closure of the critical period. [14] [15] [16] [17]
Treatment with NMDA receptor antagonist such as ketamine, PCP, or MK-801 that disrupt the NMDAR-mediated input to PV+ Interneurons have the potential to modulate critical period plasticity [18]
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cite journal}}
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