Submission declined on 14 April 2024 by
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Desmethylzopiclone, also known as SEP-174559, is an active metabolite of the sedative-hypnotic drug zolpiclone.
Unlike its parent compound, which is a largely non-selective benzodiazepine site agonist, Desmethylzopiclone is a selective partial agonist at the benzodiazepine site of α3-containing GABA receptor subtypes. [1] It is also an antagonist to nicotinic acetylcholine and NMDA receptors. [1]
Desmethylzopiclone has been described as a potential anxio-selective metabolite of zolpicloning owing to its selective affinity for the modulation of α3-containing GABA receptor subtypes. [1] These GABA-A subtypes have been implicated as key mediators of the anxiolytic effects of benzodiazepines. [2]
The quantification of desmethylzopiclone from urine has been demonstrated and may serve useful in forensic analysis of cases involving zolpiclone intoxication. [3]
Submission declined on 14 April 2024 by
Urban Versis 32 (
talk). This draft's references do not show that the subject
qualifies for a Wikipedia article. In summary, the draft needs multiple published sources that are:
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How to improve a draft
You can also browse Wikipedia:Featured articles and Wikipedia:Good articles to find examples of Wikipedia's best writing on topics similar to your proposed article. Improving your odds of a speedy review To improve your odds of a faster review, tag your draft with relevant WikiProject tags using the button below. This will let reviewers know a new draft has been submitted in their area of interest. For instance, if you wrote about a female astronomer, you would want to add the Biography, Astronomy, and Women scientists tags. Editor resources
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Desmethylzopiclone, also known as SEP-174559, is an active metabolite of the sedative-hypnotic drug zolpiclone.
Unlike its parent compound, which is a largely non-selective benzodiazepine site agonist, Desmethylzopiclone is a selective partial agonist at the benzodiazepine site of α3-containing GABA receptor subtypes. [1] It is also an antagonist to nicotinic acetylcholine and NMDA receptors. [1]
Desmethylzopiclone has been described as a potential anxio-selective metabolite of zolpicloning owing to its selective affinity for the modulation of α3-containing GABA receptor subtypes. [1] These GABA-A subtypes have been implicated as key mediators of the anxiolytic effects of benzodiazepines. [2]
The quantification of desmethylzopiclone from urine has been demonstrated and may serve useful in forensic analysis of cases involving zolpiclone intoxication. [3]
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