all-cis-7,10,13,16-docosatetraenoic acid is an
ω-6 fatty acid with the
common nameadrenic acid (AdA). This is a naturally occurring
polyunsaturated fatty acid formed through a 2-carbon chain elongation of
arachidonic acid. It is one of the most abundant fatty acids in the early human brain.[1] This unsaturated fatty acid is also metabolized by cells to biologically active products viz., dihomoprostaglandins,[2] and epoxydocosatrienoic acids (EDTs, also known as dihomo-
EETs).[3][4][5] In addition to being
endothelium-derived hyperpolarizing factors, EDTs have demonstrated anti-
endoplasmic reticulum stress and anti-
nociceptive activities. They are hydrolyzed by the
soluble epoxide hydrolase (sEH) to dihydroxydocosatrienoic acids (DHDTs) and hence might play a role in the efficacy of sEH inhibitors.
^Martinez M (1992). "Tissue levels of polyunsaturated fatty acids during early human development". J Pediatr. 120 (4 Pt 2): S129–38.
doi:
10.1016/S0022-3476(05)81247-8.
PMID1532827.
^Campbell WB,
Falck JR, Okita JR, Johnson AR, Callahan KS (1985). "Synthesis of dihomoprostaglandins from adrenic acid (7,10,13,16-docosatetraenoic acid) by human endothelial cells". Biochim. Biophys. Acta. 837 (1): 67–76.
doi:
10.1016/0005-2760(85)90086-4.
PMID3931686.
Ferretti, A., Flanagan, V.P. Mass spectrometric evidence for the conversion of exogenous adrenate to dihomo-prostaglandins by seminal vesicle cyclo-oxygenase. A comparative study of two animal species. J Chromatogr 383 241-250 (1986).
Sprecher, H., VanRollins, M., Sun, F., et al. Dihomo-prostaglandins and -thromboxane. A prostaglandin family from adrenic acid that may be preferentially synthesized in the kidney. J Biol Chem 257 3912-3918 (1982).
all-cis-7,10,13,16-docosatetraenoic acid is an
ω-6 fatty acid with the
common nameadrenic acid (AdA). This is a naturally occurring
polyunsaturated fatty acid formed through a 2-carbon chain elongation of
arachidonic acid. It is one of the most abundant fatty acids in the early human brain.[1] This unsaturated fatty acid is also metabolized by cells to biologically active products viz., dihomoprostaglandins,[2] and epoxydocosatrienoic acids (EDTs, also known as dihomo-
EETs).[3][4][5] In addition to being
endothelium-derived hyperpolarizing factors, EDTs have demonstrated anti-
endoplasmic reticulum stress and anti-
nociceptive activities. They are hydrolyzed by the
soluble epoxide hydrolase (sEH) to dihydroxydocosatrienoic acids (DHDTs) and hence might play a role in the efficacy of sEH inhibitors.
^Martinez M (1992). "Tissue levels of polyunsaturated fatty acids during early human development". J Pediatr. 120 (4 Pt 2): S129–38.
doi:
10.1016/S0022-3476(05)81247-8.
PMID1532827.
^Campbell WB,
Falck JR, Okita JR, Johnson AR, Callahan KS (1985). "Synthesis of dihomoprostaglandins from adrenic acid (7,10,13,16-docosatetraenoic acid) by human endothelial cells". Biochim. Biophys. Acta. 837 (1): 67–76.
doi:
10.1016/0005-2760(85)90086-4.
PMID3931686.
Ferretti, A., Flanagan, V.P. Mass spectrometric evidence for the conversion of exogenous adrenate to dihomo-prostaglandins by seminal vesicle cyclo-oxygenase. A comparative study of two animal species. J Chromatogr 383 241-250 (1986).
Sprecher, H., VanRollins, M., Sun, F., et al. Dihomo-prostaglandins and -thromboxane. A prostaglandin family from adrenic acid that may be preferentially synthesized in the kidney. J Biol Chem 257 3912-3918 (1982).