Dinaciclib (SCH-727965) is an experimental drug that inhibits
cyclin-dependent kinases (CDKs).[1] It is being evaluated in clinical trials for various cancer indications.[2]
Dinacliclib induces the apoptosis of osteosarcoma cells.[9]
Apoptosis of osteosarcoma cultures can be induced by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor.[10]
Role in developing neurons
In primary cultured neurons, dinaciclib regulates neurogenesis, where it reduces expression of upper layer marker
Satb2, and induces
CTIP2, expressed in neurons of deeper layers.[11]
^Ambrozkiewicz MC, Bessa P, Salazar-Lázaro A, Salina V, Tarabykin V (November 2017). "Satb2Cre/+ mouse as a tool to investigate cell fate determination in the developing neocortex". Journal of Neuroscience Methods. 291: 113–121.
doi:
10.1016/j.jneumeth.2017.07.023.
PMID28782628.
S2CID140208929.
^Mita MM, Joy AA, Mita A, Sankhala K, Jou YM, Zhang D, et al. (June 2014). "Randomized phase II trial of the cyclin-dependent kinase inhibitor dinaciclib (MK-7965) versus capecitabine in patients with advanced breast cancer". Clinical Breast Cancer. 14 (3): 169–176.
doi:
10.1016/j.clbc.2013.10.016.
PMID24393852.
^Stephenson JJ, Nemunaitis J, Joy AA, Martin JC, Jou YM, Zhang D, et al. (February 2014). "Randomized phase 2 study of the cyclin-dependent kinase inhibitor dinaciclib (MK-7965) versus erlotinib in patients with non-small cell lung cancer". Lung Cancer. 83 (2): 219–223.
doi:
10.1016/j.lungcan.2013.11.020.
PMID24388167.
^Clinical trial number NCT01096342 for "Phase II Trial of CDK Inhibitor Sch 727965 in Multiple Myeloma" at
ClinicalTrials.gov
^Clinical trial number NCT01580228 for "A Phase 3 Study to Evaluate the Efficacy and Safety of Dinaciclib or Ofatumumab in Subjects with Refractory Chronic Lymphocytic Leukemia" at
ClinicalTrials.gov
Dinaciclib (SCH-727965) is an experimental drug that inhibits
cyclin-dependent kinases (CDKs).[1] It is being evaluated in clinical trials for various cancer indications.[2]
Dinacliclib induces the apoptosis of osteosarcoma cells.[9]
Apoptosis of osteosarcoma cultures can be induced by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor.[10]
Role in developing neurons
In primary cultured neurons, dinaciclib regulates neurogenesis, where it reduces expression of upper layer marker
Satb2, and induces
CTIP2, expressed in neurons of deeper layers.[11]
^Ambrozkiewicz MC, Bessa P, Salazar-Lázaro A, Salina V, Tarabykin V (November 2017). "Satb2Cre/+ mouse as a tool to investigate cell fate determination in the developing neocortex". Journal of Neuroscience Methods. 291: 113–121.
doi:
10.1016/j.jneumeth.2017.07.023.
PMID28782628.
S2CID140208929.
^Mita MM, Joy AA, Mita A, Sankhala K, Jou YM, Zhang D, et al. (June 2014). "Randomized phase II trial of the cyclin-dependent kinase inhibitor dinaciclib (MK-7965) versus capecitabine in patients with advanced breast cancer". Clinical Breast Cancer. 14 (3): 169–176.
doi:
10.1016/j.clbc.2013.10.016.
PMID24393852.
^Stephenson JJ, Nemunaitis J, Joy AA, Martin JC, Jou YM, Zhang D, et al. (February 2014). "Randomized phase 2 study of the cyclin-dependent kinase inhibitor dinaciclib (MK-7965) versus erlotinib in patients with non-small cell lung cancer". Lung Cancer. 83 (2): 219–223.
doi:
10.1016/j.lungcan.2013.11.020.
PMID24388167.
^Clinical trial number NCT01096342 for "Phase II Trial of CDK Inhibitor Sch 727965 in Multiple Myeloma" at
ClinicalTrials.gov
^Clinical trial number NCT01580228 for "A Phase 3 Study to Evaluate the Efficacy and Safety of Dinaciclib or Ofatumumab in Subjects with Refractory Chronic Lymphocytic Leukemia" at
ClinicalTrials.gov