![]() | This article needs more
reliable medical references for
verification or relies too heavily on
primary sources. (June 2016) | ![]() |
![]() | |
Names | |
---|---|
Preferred IUPAC name
3,3′-Methylenedi(1H-indole) | |
Other names
3-(1H-Indol-3-ylmethyl)-1H-indole
3,3′-Methylenebis-1H-indole DIM | |
Identifiers | |
3D model (
JSmol)
|
|
223072 | |
ChEBI | |
ChEMBL | |
ChemSpider | |
DrugBank | |
ECHA InfoCard | 100.124.716 |
EC Number |
|
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C17H14N2 | |
Molar mass | 246.313 g·mol−1 |
Hazards | |
GHS labelling: | |
![]() | |
Warning | |
H315, H319, H335, H413 | |
P261, P264, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501 | |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
3,3′-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage and kale. [1] It and its parent compound – indole-3-carbinol – are under laboratory research to determine their possible biological properties, particularly in anti-cancer mechanisms. [1] [2] [3] DIM is sold as a dietary supplement. [1]
In vitro, DIM has action as a histone deacetylase inhibitor, [1] specifically against HDAC1, HDAC2, and HDAC3. [4] DIM is a metabolite of indole-3-carbinol. [1] [2] [3] DIM was found to be a mild cannabinoid agonist with low binding affinity for both CB1 and CB2. [5] [6]
Researchers from Ben-Gurion University of the Negev, in collaboration with teams from Sichuan University and the National University of Singapore, have identified that 3,3′-Diindolylmethane (DIM) – a naturally occurring molecule also referred to as bisindole – can reduce biofilms responsible for plaque and cavities by a remarkable 90%. [7]
![]() | This article needs more
reliable medical references for
verification or relies too heavily on
primary sources. (June 2016) | ![]() |
![]() | |
Names | |
---|---|
Preferred IUPAC name
3,3′-Methylenedi(1H-indole) | |
Other names
3-(1H-Indol-3-ylmethyl)-1H-indole
3,3′-Methylenebis-1H-indole DIM | |
Identifiers | |
3D model (
JSmol)
|
|
223072 | |
ChEBI | |
ChEMBL | |
ChemSpider | |
DrugBank | |
ECHA InfoCard | 100.124.716 |
EC Number |
|
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C17H14N2 | |
Molar mass | 246.313 g·mol−1 |
Hazards | |
GHS labelling: | |
![]() | |
Warning | |
H315, H319, H335, H413 | |
P261, P264, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501 | |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
3,3′-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage and kale. [1] It and its parent compound – indole-3-carbinol – are under laboratory research to determine their possible biological properties, particularly in anti-cancer mechanisms. [1] [2] [3] DIM is sold as a dietary supplement. [1]
In vitro, DIM has action as a histone deacetylase inhibitor, [1] specifically against HDAC1, HDAC2, and HDAC3. [4] DIM is a metabolite of indole-3-carbinol. [1] [2] [3] DIM was found to be a mild cannabinoid agonist with low binding affinity for both CB1 and CB2. [5] [6]
Researchers from Ben-Gurion University of the Negev, in collaboration with teams from Sichuan University and the National University of Singapore, have identified that 3,3′-Diindolylmethane (DIM) – a naturally occurring molecule also referred to as bisindole – can reduce biofilms responsible for plaque and cavities by a remarkable 90%. [7]