catenin (cadherin-associated protein), delta 1 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | CTNND1 | ||||||
Alt. symbols | CTNND | ||||||
NCBI gene | 1500 | ||||||
HGNC | 2515 | ||||||
OMIM | 601045 | ||||||
RefSeq | NM_001331 | ||||||
UniProt | O60716 | ||||||
Other data | |||||||
Locus | Chr. 11 q12.1 | ||||||
|
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | CTNND2 | ||||||
NCBI gene | 1501 | ||||||
HGNC | 2516 | ||||||
OMIM | 604275 | ||||||
RefSeq | NM_001332 | ||||||
UniProt | Q9UQB3 | ||||||
Other data | |||||||
Locus | Chr. 5 p15.2 | ||||||
|
δ-Catenin is a subfamily of catenin proteins with ten armadillo-repeats and includes the proteins catenin delta-1 and catenin delta-2. Catenin delta-2 is expressed in the brain where it is important for normal cognitive development. [1] Like β-catenin and γ-catenin, δ-catenins seem to interact with presenilins. [2] These catenin-presenilin interaction have implications for cadherin function and regulation of cell-to-cell adhesion. [3]
While β-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-1 catenin has been implicated as a regulator of the NF-κB transcription factor. [4]
Palmitoylation of δ-catenin seems to coordinate activity-dependent changes in synaptic adhesion molecules, synapse structure, and receptor localizations that are involved in memory formation. [5]
catenin (cadherin-associated protein), delta 1 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | CTNND1 | ||||||
Alt. symbols | CTNND | ||||||
NCBI gene | 1500 | ||||||
HGNC | 2515 | ||||||
OMIM | 601045 | ||||||
RefSeq | NM_001331 | ||||||
UniProt | O60716 | ||||||
Other data | |||||||
Locus | Chr. 11 q12.1 | ||||||
|
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | CTNND2 | ||||||
NCBI gene | 1501 | ||||||
HGNC | 2516 | ||||||
OMIM | 604275 | ||||||
RefSeq | NM_001332 | ||||||
UniProt | Q9UQB3 | ||||||
Other data | |||||||
Locus | Chr. 5 p15.2 | ||||||
|
δ-Catenin is a subfamily of catenin proteins with ten armadillo-repeats and includes the proteins catenin delta-1 and catenin delta-2. Catenin delta-2 is expressed in the brain where it is important for normal cognitive development. [1] Like β-catenin and γ-catenin, δ-catenins seem to interact with presenilins. [2] These catenin-presenilin interaction have implications for cadherin function and regulation of cell-to-cell adhesion. [3]
While β-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-1 catenin has been implicated as a regulator of the NF-κB transcription factor. [4]
Palmitoylation of δ-catenin seems to coordinate activity-dependent changes in synaptic adhesion molecules, synapse structure, and receptor localizations that are involved in memory formation. [5]