C4-dicarboxylate anaerobic carrier | |||||||||
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Identifiers | |||||||||
Symbol | DcuC | ||||||||
Pfam | PF03606 | ||||||||
Pfam clan | CL0182 | ||||||||
InterPro | IPR018385 | ||||||||
TCDB | 9.B.50 | ||||||||
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The C4-dicarboxylate uptake C family or DcuC family ( TC# 2.A.61) is a family of transmembrane ion transporters found in bacteria. [1] A representative list of proteins belonging to the DcuC family can be found in the Transporter Classification Database.
An anaerobic C4-dicarboxylate transporter (DcuC) of E. coli ( TC# 2.A.61.1.1) has 14 putative transmembrane regions, is induced only under anaerobic conditions, and is not repressed by glucose. DcuC may therefore function as a succinate efflux system during anaerobic glucose fermentation. However, when overexpressed, it can replace either DcuA or DcuB in catalysing fumarate-succinate exchange and fumarate uptake. [2] [3] DcuC shows the same transport modes as DcuA and DcuB (exchange, uptake, and presumably efflux of C4-dicarboxylates). [4] [5]
The reactions probably catalyzed by the E. coli DcuC protein are:
C4-dicarboxylate anaerobic carrier | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | DcuC | ||||||||
Pfam | PF03606 | ||||||||
Pfam clan | CL0182 | ||||||||
InterPro | IPR018385 | ||||||||
TCDB | 9.B.50 | ||||||||
|
The C4-dicarboxylate uptake C family or DcuC family ( TC# 2.A.61) is a family of transmembrane ion transporters found in bacteria. [1] A representative list of proteins belonging to the DcuC family can be found in the Transporter Classification Database.
An anaerobic C4-dicarboxylate transporter (DcuC) of E. coli ( TC# 2.A.61.1.1) has 14 putative transmembrane regions, is induced only under anaerobic conditions, and is not repressed by glucose. DcuC may therefore function as a succinate efflux system during anaerobic glucose fermentation. However, when overexpressed, it can replace either DcuA or DcuB in catalysing fumarate-succinate exchange and fumarate uptake. [2] [3] DcuC shows the same transport modes as DcuA and DcuB (exchange, uptake, and presumably efflux of C4-dicarboxylates). [4] [5]
The reactions probably catalyzed by the E. coli DcuC protein are: