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| ChemSpider | |
| CompTox Dashboard ( EPA) | |
| Chemical and physical data | |
| Formula | C16H21NO3 |
| Molar mass | 275.348 g·mol−1 |
| 3D model ( JSmol) | |
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Datumetine is a tropane alkaloid found in leaves of Datura metel. [1] It is said to modulate NMDA receptor and thus causes memory loss. [2] It also causes epileptic seizures in mice. [2] Docking studies suggest that it fits on both allosteric and orthosteric sites of NMDA receptor. [2] It acts together with other anticholinergic tropane alkaloids of datura to cause amnesia.[ citation needed]
- ^ Siddiqui S, Sultana N, Ahmed SS, Haider SI (2004). "Isolation and Structure of a New Alkaloid Datumetine from the leaves of Datura metel". Journal of Natural Products. 49 (3): 511–513. doi: 10.1021/np50045a023. ISSN 0163-3864.
- ^ a b c Ishola AO, Imam A, Ajao MS (2021). "Effects of datumetine on hippocampal NMDAR activity". Toxicology Reports. 8: 1131–1142. doi: 10.1016/j.toxrep.2021.05.009. PMC 8190477. PMID 34150523.
 | This article about an alkaloid is a stub. You can help Wikipedia by expanding it. |
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| Identifiers | |
|---|---|
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| CompTox Dashboard ( EPA) | |
| Chemical and physical data | |
| Formula | C16H21NO3 |
| Molar mass | 275.348 g·mol−1 |
| 3D model ( JSmol) | |
| |
| |
Datumetine is a tropane alkaloid found in leaves of Datura metel. [1] It is said to modulate NMDA receptor and thus causes memory loss. [2] It also causes epileptic seizures in mice. [2] Docking studies suggest that it fits on both allosteric and orthosteric sites of NMDA receptor. [2] It acts together with other anticholinergic tropane alkaloids of datura to cause amnesia.[ citation needed]
- ^ Siddiqui S, Sultana N, Ahmed SS, Haider SI (2004). "Isolation and Structure of a New Alkaloid Datumetine from the leaves of Datura metel". Journal of Natural Products. 49 (3): 511–513. doi: 10.1021/np50045a023. ISSN 0163-3864.
- ^ a b c Ishola AO, Imam A, Ajao MS (2021). "Effects of datumetine on hippocampal NMDAR activity". Toxicology Reports. 8: 1131–1142. doi: 10.1016/j.toxrep.2021.05.009. PMC 8190477. PMID 34150523.
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| This article about an alkaloid is a stub. You can help Wikipedia by expanding it. |