From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Cytoplasmic dynein 1 intermediate chain 1 is a
protein that in humans is encoded by the DYNC1I1
gene .
[5]
[6]
[7]
In melanocytic cells DYNC1I1 gene expression may be regulated by
MITF .
[8]
Interactions
DYNC1I1 has been shown to
interact with
DYNLL1 .
[9]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000158560 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000029757 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC (May 1999). "Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human". Genomics . 55 (3): 257–67.
doi :
10.1006/geno.1998.5665 .
PMID
10049579 .
^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005).
"Cytoplasmic dynein nomenclature" . J Cell Biol . 171 (3): 411–3.
doi :
10.1083/jcb.200508078 .
PMC
2171247 .
PMID
16260502 .
^
"Entrez Gene: DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1" .
^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008).
"Novel MITF targets identified using a two-step DNA microarray strategy" . Pigment Cell Melanoma Res . 21 (6): 665–76.
doi :
10.1111/j.1755-148X.2008.00505.x .
PMID
19067971 .
S2CID
24698373 .
^ Diefenbach, Russell J; Diefenbach Eve; Douglas Mark W; Cunningham Anthony L (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry . 41 (50). United States: 14906–15.
doi :
10.1021/bi026417u .
ISSN
0006-2960 .
PMID
12475239 .
Further reading
King SM, Dillman JF, Benashski SE, et al. (1997).
"The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein" . J. Biol. Chem . 271 (50): 32281–7.
doi :
10.1074/jbc.271.50.32281 .
PMID
8943288 .
Lo KW, Naisbitt S, Fan JS, et al. (2001).
"The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif" . J. Biol. Chem . 276 (17): 14059–66.
doi :
10.1074/jbc.M010320200 .
PMID
11148209 .
Horikawa I, Parker ES, Solomon GG, Barrett JC (2001).
"Upregulation of the gene encoding a cytoplasmic dynein intermediate chain in senescent human cells" . J. Cell. Biochem . 82 (3): 415–21.
doi :
10.1002/jcb.1169 .
PMID
11500918 .
S2CID
10899690 .
Karki S, Ligon LA, DeSantis J, et al. (2002).
"PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact" . Mol. Biol. Cell . 13 (5): 1722–34.
doi :
10.1091/mbc.02-02-0011 .
PMC
111139 .
PMID
12006665 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Scherer SW, Cheung J, MacDonald JR, et al. (2003).
"Human chromosome 7: DNA sequence and biology" . Science . 300 (5620): 767–72.
Bibcode :
2003Sci...300..767S .
doi :
10.1126/science.1083423 .
PMC
2882961 .
PMID
12690205 .
Hillier LW, Fulton RS, Fulton LA, et al. (2003).
"The DNA sequence of human chromosome 7" . Nature . 424 (6945): 157–64.
Bibcode :
2003Natur.424..157H .
doi :
10.1038/nature01782 .
PMID
12853948 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Ligon LA, Tokito M, Finklestein JM, et al. (2004).
"A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity" . J. Biol. Chem . 279 (18): 19201–8.
doi :
10.1074/jbc.M313472200 .
PMID
14985359 .
Villacé P, Marión RM, Ortín J (2004).
"The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs" . Nucleic Acids Res . 32 (8): 2411–20.
doi :
10.1093/nar/gkh552 .
PMC
419443 .
PMID
15121898 .
Chuang JZ, Yeh TY, Bollati F, et al. (2005).
"The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth" . Dev. Cell . 9 (1): 75–86.
doi :
10.1016/j.devcel.2005.04.003 .
PMC
3857739 .
PMID
15992542 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .