From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Segment polarity protein dishevelled homolog DVL-3 is a
protein that in humans is encoded by the DVL3
gene .
[5]
[6]
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.
[6]
Interactions
DVL3 has been shown to
interact with
DAB2 ,
[7]
DVL1
[8] and
PRPF3 .
[9]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000161202 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000003233 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, Giardino L, Ratti A, Penso D, Calza L, Palka G, Scarlato G, Novelli G, Dallapiccola B (January 1997).
"cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene" . Hum Mol Genet . 5 (7): 953–958.
doi :
10.1093/hmg/5.7.953 .
PMID
8817329 .
^
a
b
"Entrez Gene: DVL3 dishevelled, dsh homolog 3 (Drosophila)" .
^ Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003).
"Regulation of the Wnt signaling pathway by disabled-2 (Dab2)" . EMBO J . 22 (12). England: 3084–3094.
doi :
10.1093/emboj/cdg286 .
ISSN
0261-4189 .
PMC
162138 .
PMID
12805222 .
^ Kishida, S; Yamamoto H; Hino S; Ikeda S; Kishida M; Kikuchi A (June 1999).
"DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability" . Mol. Cell. Biol . 19 (6). UNITED STATES: 4414–4422.
doi :
10.1128/mcb.19.6.4414 .
ISSN
0270-7306 .
PMC
104400 .
PMID
10330181 .
^ Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
Nature . 437 (7062). England: 1173–1178.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Further reading
Nagase T, Seki N, Ishikawa K, et al. (1997).
"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain" . DNA Res . 3 (5): 321–329, 341–54.
doi :
10.1093/dnares/3.5.321 .
PMID
9039502 .
Semënov MV, Snyder M (1997).
"Human dishevelled genes constitute a DHR-containing multigene family" . Genomics . 42 (2): 302–310.
doi :
10.1006/geno.1997.4713 .
PMID
9192851 .
Bui TD, Beier DR, Jonssen M, et al. (1997). "cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas". Biochem. Biophys. Res. Commun . 239 (2): 510–516.
doi :
10.1006/bbrc.1997.7500 .
PMID
9344861 .
Kishida S, Yamamoto H, Hino S, et al. (1999).
"DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability" . Mol. Cell. Biol . 19 (6): 4414–4422.
doi :
10.1128/mcb.19.6.4414 .
PMC
104400 .
PMID
10330181 .
Song DH, Sussman DJ, Seldin DC (2000).
"Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells" . J. Biol. Chem . 275 (31): 23790–23797.
doi :
10.1074/jbc.M909107199 .
PMID
10806215 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Hocevar BA, Mou F, Rennolds JL, et al. (2003).
"Regulation of the Wnt signaling pathway by disabled-2 (Dab2)" . EMBO J . 22 (12): 3084–3094.
doi :
10.1093/emboj/cdg286 .
PMC
162138 .
PMID
12805222 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–45.
doi :
10.1038/ng1285 .
PMID
14702039 .
Torban E, Wang HJ, Groulx N, Gros P (2005).
"Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family" . J. Biol. Chem . 279 (50): 52703–52713.
doi :
10.1074/jbc.M408675200 .
PMID
15456783 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–1178.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Chan DW, Chan CY, Yam JW, et al. (2006).
"Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer" . Gastroenterology . 131 (4): 1218–1227.
doi :
10.1053/j.gastro.2006.07.020 .
PMID
17030191 .