From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Dermatan-sulfate epimerase is an
enzyme that in humans is encoded by the DSE
gene .
[5]
[6]
[7]
[8]
[9]
The protein encoded by this gene is an
epimerase required for biosynthesis of
dermatan sulfate
[10] and a tumor-rejection
antigen . This antigen possesses tumor
epitopes capable of inducing
HLA-A24 -restricted and tumor-specific cytotoxic
T lymphocytes in cancer patients and may be useful for specific
immunotherapy . This gene product is localized to the
endoplasmic reticulum . Two transcript variants encoding the same protein have been found for this gene.
[7]
Clinical significance
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000111817 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000039497 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (Mar 2002).
"Expression of tumor rejection antigens in colorectal carcinomas" . Cancer . 94 (6): 1636–41.
doi :
10.1002/cncr.10421 .
PMID
11920522 .
S2CID
33045822 .
^ Maccarana M, Olander B, Malmstrom J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmstrom A (Apr 2006).
"Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2" . J Biol Chem . 281 (17): 11560–8.
doi :
10.1074/jbc.M513373200 .
PMID
16505484 .
^
a
b
"Entrez Gene: DSE dermatan sulfate epimerase" .
^ Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (March 2002).
"Expression of tumor rejection antigens in colorectal carcinomas" . Cancer . 94 (6): 1636–41.
doi :
10.1002/cncr.10421 .
PMID
11920522 .
S2CID
33045822 .
^ Maccarana M, Olander B, Malmström J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmström A (April 2006).
"Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2" . J. Biol. Chem . 281 (17): 11560–8.
doi :
10.1074/jbc.M513373200 .
PMID
16505484 .
^ Malstrom, Anders (1982).
"Biosynthesis of dermatan sulphate: Assay and properties of the uronosyl C-5 epimerase" . Biochem. J . 201 (3): 489–93.
doi :
10.1042/bj2010489 .
PMC
1163673 .
PMID
7092807 .
Further reading
Nakao M, Shichijo S, Imaizumi T, et al. (2000).
"Identification of a gene coding for a new squamous cell carcinoma antigen recognized by the CTL" . J. Immunol . 164 (5): 2565–74.
doi :
10.4049/jimmunol.164.5.2565 .
PMID
10679095 .
Tanaka S, Tsuda N, Kawano K, et al. (2001).
"Expression of tumor-rejection antigens in gynecologic cancers" . Jpn. J. Cancer Res . 91 (11): 1177–84.
doi :
10.1111/j.1349-7006.2000.tb00902.x .
PMC
5926290 .
PMID
11092984 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Mungall AJ, Palmer SA, Sims SK, et al. (2003).
"The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11.
Bibcode :
2003Natur.425..805M .
doi :
10.1038/nature02055 .
PMID
14574404 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
"Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65.
doi :
10.1101/gr.4039406 .
PMC
1356129 .
PMID
16344560 .