DREAM Challenges (Dialogue for Reverse Engineering Assessment and Methods) is a non-profit initiative for advancing biomedical and systems biology research via crowd-sourced competitions. ^{[1] [2]} Started in 2006, DREAM challenges collaborate with Sage Bionetworks to provide a platform for competitions run on the Synapse platform. Over 60 DREAM challenges have been conducted over the span of over 15 years. ^[3]

Overview

DREAM Challenges were founded in 2006 by Gustavo Stolovizky from IBM Research ^[4] and Andrea Califano from Columbia University. Current chair of the DREAM organization is Paul Boutros from University of California. Further organization spans emeritus chairs Justin Guinney and Gustavo Stolovizky, and multiple DREAM directors. ^[5]

Individual challenges focus on tackling a specific biomedical research question, typically narrowed down to a specific disease. A prominent disease focus has been on oncology, with multiple past challenges focused on breast cancer, acute myeloid leukemia, and prostate cancer or similar diseases. ^[3] The data involved in an individual challenge reflects the disease context; while cancers typically involve data such as mutations in the human genome, gene expression and gene networks in transcriptomics, and large scale proteomics, newer challenges have shifted towards single cell sequencing technologies as well as emerging gut microbiome related research questions, thus reflecting trends in the wider research community. ^[6]

Motivation for DREAM Challenges is that via crowd-sourcing data to a larger audience via competitions, better models and insight is gained than if the analysis was conducted by a single entity. ^[7] Past competitions have been published in such scientific venues as the flagship journals of the Nature Portfolio and PLOS publishing groups. ^[8] Results of DREAM challenges are announced via web platforms, and the top performing participants are invited to present their results in the annual RECOMB/ ISCB Conferences with RSG/DREAM ^[9] organized by the ISCB.

While DREAM Challenges have emphasized open science and data, in order to mitigate issues rising from highly sensitive data such as genomics in patient cohorts, "model to data" approaches have been adopted. ^[10] In such challenges participants submit their models via containers such as Docker or Singularity. This allows retaining confidentiality of the original data as these containers are then run by the organizers on the confidential data. This differs from the more traditional open data model, where participants submit predictions directly based on the provided open data.

Challenge organization

DREAM challenge comprises a core DREAM/ Sage Bionetworks organization group as well as an extended scientific expert group, who may have contributed to creation and conception of the challenge or by providing key data. ^[11] Additionally, new DREAM challenges may be proposed by the wider research community. ^[12] Pharmaceutical companies or other private entities may also be involved in DREAM challenges, for example in providing data.

Challenge structure

Timelines for key stages (such as introduction webinars, model submission deadlines, and final deadline for participation) are provided in advance. After the winners are announced, organizers start collaborating with the top performing participants to conduct post hoc analyses for a publication describing key findings from the competition. ^[7]

Challenges may be split into sub-challenges, each addressing a different subtopic within the research question. For example, regarding cancer treatment efficacy predictions, these may be separate predictions for progression-free survival, overall survival, best overall response according to RECIST, or exact time until event (progression or death). ^[2]

Participation

During DREAM challenges, participants typically build models on provided data, and submit predictions or models that are then validated on held-out data by the organizers. While DREAM challenges avoid leaking validation data to participants, there are typically mid-challenge submission leaderboards available to assist participants in evaluating their performance on a sub-sampled or scrambled dataset. ^[7]

DREAM challenges are free for participants. During the open phase anybody can register via Synapse to participate either individually or as a team. A person may only register once and may not use any aliases.

There are some exceptions, which disqualify an individual from participating, for example: ^[13]

• Person has privileged access to the data for the particular challenge, thus providing them with an unfair advantage.
• Person has been caught or is under suspicion of cheating or abusing previous DREAM Challenges.
• Person is a minor (under age 18 or the age of majority in jurisdiction of residence). This may be alleviated via parental consent.

See also

• List of crowdsourcing projects
• Critical Assessment of Function Annotation (CAFA)
• Critical Assessment of Genome Interpretation (CAGI)
• Critical Assessment of Prediction of Interactions (CAPRI)
• Critical Assessment of protein Structure Prediction (CASP)
• Kaggle

References