Protein delta homolog 1, delta like non-canonical Notch ligand 1, fetal antigen 1[5] or preadipocyte factor 1[6] is a
protein that in humans is encoded by the DLK1gene.[7][8][9]
Part of the Dlk1-
DIO3imprinting control region, this gene is one involved in the
epigenetic process that causes a subset of genes to be regulated based on their parental origin.[13]
Such imprinted genes are required for the formation of the
placenta as well as the development of cellular lineages such as those derived from the
mesoderm and
ectoderm.[14]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Jensen C, Teisner B, Højrup P, Rasmussen H, Madsen O, Nielsen B, Skjødt K (1993). "Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2". Human Reproduction. 8 (4): 635–641.
doi:
10.1093/oxfordjournals.humrep.a138110.
PMID8501199.
^Jensen CH, Krogh TN, Højrup P, Clausen PP, Skjødt K, Larsson LI, Enghild JJ, Teisner B (1994). "Protein Structure of Fetal Antigen 1 (FA1). A Novel Circulating Human Epidermal-Growth-Factor-Like Protein Expressed in Neuroendocrine Tumors and its Relation to the Gene Products of Dlk and pG2". European Journal of Biochemistry. 225 (1): 83–92.
doi:
10.1111/j.1432-1033.1994.00083.x.
PMID7925474.
^Laborda J (2000). "The role of the epidermal growth factor-like protein dlk in cell differentiation". Histology and Histopathology. 15 (1): 119–29.
PMID10668203.
Lee YL, Helman L, Hoffman T, Laborda J (1995). "Dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1261 (2): 223–32.
doi:
10.1016/0167-4781(95)00007-4.
PMID7711066.
Jensen CH, Teisner B, Højrup P, Rasmussen HB, Madsen OD, Nielsen B, Skjødt K (1993). "Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2". Human Reproduction. 8 (4): 635–41.
doi:
10.1093/oxfordjournals.humrep.a138110.
PMID8501199.
Tornehave D, Jensen CH, Teisner B, Larsson LI (1996). "FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression". Histochemistry and Cell Biology. 106 (6): 535–42.
doi:
10.1007/BF02473268.
PMID8985741.
S2CID19673701.
Jensen CH, Schroder HD, Teisner B, Laursen I, Brandrup F, Rasmussen HB (1999). "Fetal antigen 1, a member of the epidermal growth factor superfamily, in neurofibromas and serum from patients with neurofibromatosis type 1". British Journal of Dermatology. 140 (6): 1054–9.
doi:
10.1046/j.1365-2133.1999.02906.x.
PMID10354070.
S2CID25598902.
Andersen M (2001). "Fetal Antigen 1 in Healthy Adults and Patients with Pituitary Disease: Relation to Physiological, Pathological, and Pharmacological GH Levels". Journal of Clinical Endocrinology & Metabolism. 86 (11): 5465–70.
doi:
10.1210/jcem.86.11.7990.
PMID11701723.
S2CID24831931.
Jensen CH, Meyer M, Schroder HD, Kliem A, Zimmer J, Teisner B (2001). "Neurons in the monoaminergic nuclei of the rat and human central nervous system express FA1/dlk". NeuroReport. 12 (18): 3959–63.
doi:
10.1097/00001756-200112210-00021.
PMID11742219.
S2CID30021418.
Abdallah BM, Jensen CH, Gutierrez G, Leslie RG, Jensen TG, Kassem M (2004). "Regulation of Human Skeletal Stem Cells Differentiation by Dlk1/Pref-1". Journal of Bone and Mineral Research. 19 (5): 841–52.
doi:
10.1359/JBMR.040118.
PMID15068508.
S2CID23774562.
Protein delta homolog 1, delta like non-canonical Notch ligand 1, fetal antigen 1[5] or preadipocyte factor 1[6] is a
protein that in humans is encoded by the DLK1gene.[7][8][9]
Part of the Dlk1-
DIO3imprinting control region, this gene is one involved in the
epigenetic process that causes a subset of genes to be regulated based on their parental origin.[13]
Such imprinted genes are required for the formation of the
placenta as well as the development of cellular lineages such as those derived from the
mesoderm and
ectoderm.[14]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Jensen C, Teisner B, Højrup P, Rasmussen H, Madsen O, Nielsen B, Skjødt K (1993). "Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2". Human Reproduction. 8 (4): 635–641.
doi:
10.1093/oxfordjournals.humrep.a138110.
PMID8501199.
^Jensen CH, Krogh TN, Højrup P, Clausen PP, Skjødt K, Larsson LI, Enghild JJ, Teisner B (1994). "Protein Structure of Fetal Antigen 1 (FA1). A Novel Circulating Human Epidermal-Growth-Factor-Like Protein Expressed in Neuroendocrine Tumors and its Relation to the Gene Products of Dlk and pG2". European Journal of Biochemistry. 225 (1): 83–92.
doi:
10.1111/j.1432-1033.1994.00083.x.
PMID7925474.
^Laborda J (2000). "The role of the epidermal growth factor-like protein dlk in cell differentiation". Histology and Histopathology. 15 (1): 119–29.
PMID10668203.
Lee YL, Helman L, Hoffman T, Laborda J (1995). "Dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1261 (2): 223–32.
doi:
10.1016/0167-4781(95)00007-4.
PMID7711066.
Jensen CH, Teisner B, Højrup P, Rasmussen HB, Madsen OD, Nielsen B, Skjødt K (1993). "Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2". Human Reproduction. 8 (4): 635–41.
doi:
10.1093/oxfordjournals.humrep.a138110.
PMID8501199.
Tornehave D, Jensen CH, Teisner B, Larsson LI (1996). "FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression". Histochemistry and Cell Biology. 106 (6): 535–42.
doi:
10.1007/BF02473268.
PMID8985741.
S2CID19673701.
Jensen CH, Schroder HD, Teisner B, Laursen I, Brandrup F, Rasmussen HB (1999). "Fetal antigen 1, a member of the epidermal growth factor superfamily, in neurofibromas and serum from patients with neurofibromatosis type 1". British Journal of Dermatology. 140 (6): 1054–9.
doi:
10.1046/j.1365-2133.1999.02906.x.
PMID10354070.
S2CID25598902.
Andersen M (2001). "Fetal Antigen 1 in Healthy Adults and Patients with Pituitary Disease: Relation to Physiological, Pathological, and Pharmacological GH Levels". Journal of Clinical Endocrinology & Metabolism. 86 (11): 5465–70.
doi:
10.1210/jcem.86.11.7990.
PMID11701723.
S2CID24831931.
Jensen CH, Meyer M, Schroder HD, Kliem A, Zimmer J, Teisner B (2001). "Neurons in the monoaminergic nuclei of the rat and human central nervous system express FA1/dlk". NeuroReport. 12 (18): 3959–63.
doi:
10.1097/00001756-200112210-00021.
PMID11742219.
S2CID30021418.
Abdallah BM, Jensen CH, Gutierrez G, Leslie RG, Jensen TG, Kassem M (2004). "Regulation of Human Skeletal Stem Cells Differentiation by Dlk1/Pref-1". Journal of Bone and Mineral Research. 19 (5): 841–52.
doi:
10.1359/JBMR.040118.
PMID15068508.
S2CID23774562.