Dickkopf-related protein 2 is a
protein in the
Dickkopf family that in humans is encoded by the DKK2gene.[5][6]
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two
cysteine rich regions and is involved in
embryonic development through its interactions with the
Wnt signaling pathway.
It can act as either an
agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (
LRP6).[6]
Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C (May 2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature. 411 (6835): 321–5.
doi:
10.1038/35077108.
PMID11357136.
S2CID4323027.
Dickkopf-related protein 2 is a
protein in the
Dickkopf family that in humans is encoded by the DKK2gene.[5][6]
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two
cysteine rich regions and is involved in
embryonic development through its interactions with the
Wnt signaling pathway.
It can act as either an
agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (
LRP6).[6]
Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C (May 2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature. 411 (6835): 321–5.
doi:
10.1038/35077108.
PMID11357136.
S2CID4323027.