Diacylglycerol kinase gamma is an
enzyme that in humans is encoded by the DGKGgene.[5][6]
This gene encodes an enzyme that is a member of the type I subfamily of
diacylglycerol kinases, which are involved in
lipid metabolism. These enzymes generate
phosphatidic acid by catalyzing the phosphorylation of
diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including
protein kinase C isoforms, Ras guanyl
nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of
macrophage differentiation in
leukemia cells. Multiple transcript variants encoding different
isoforms have been found for this gene.[6]
Brose N, Betz A, Wegmeyer H (2004). "Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals". Curr. Opin. Neurobiol. 14 (3): 328–40.
doi:
10.1016/j.conb.2004.05.006.
PMID15194113.
S2CID7070625.
Stöhr H, Klein J, Gehrig A, et al. (1999). "Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1)". Hum. Genet. 104 (1): 99–105.
doi:
10.1007/s004390050917.
PMID10071200.
S2CID19248400.
Yamada K, Sakane F, Imai S, et al. (2003). "Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cells". Biochem. Biophys. Res. Commun. 305 (1): 101–7.
doi:
10.1016/S0006-291X(03)00713-7.
PMID12732202.
Oyaizu K, Kantarci A, Maeda H, et al. (2003). "Identification of mRNAs for the various diacylglycerol kinase isoforms in neutrophils from patients with localized aggressive periodontitis". J. Periodont. Res. 38 (5): 488–95.
doi:
10.1034/j.1600-0765.2003.00680.x.
PMID12941073.
Filosto M, Mancuso M, Tomelleri G, et al. (2004). "Hepato-cerebral syndrome: genetic and pathological studies in an infant with a dGK mutation". Acta Neuropathol. 108 (2): 168–71.
doi:
10.1007/s00401-004-0872-9.
PMID15150663.
S2CID31732164.
Batista EL, Warbington M, Badwey JA, Van Dyke TE (2005). "Differentiation of HL-60 cells to granulocytes involves regulation of select diacylglycerol kinases (DGKs)". J. Cell. Biochem. 94 (4): 774–93.
doi:
10.1002/jcb.20356.
PMID15578578.
S2CID114877.
Diacylglycerol kinase gamma is an
enzyme that in humans is encoded by the DGKGgene.[5][6]
This gene encodes an enzyme that is a member of the type I subfamily of
diacylglycerol kinases, which are involved in
lipid metabolism. These enzymes generate
phosphatidic acid by catalyzing the phosphorylation of
diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including
protein kinase C isoforms, Ras guanyl
nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of
macrophage differentiation in
leukemia cells. Multiple transcript variants encoding different
isoforms have been found for this gene.[6]
Brose N, Betz A, Wegmeyer H (2004). "Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals". Curr. Opin. Neurobiol. 14 (3): 328–40.
doi:
10.1016/j.conb.2004.05.006.
PMID15194113.
S2CID7070625.
Stöhr H, Klein J, Gehrig A, et al. (1999). "Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1)". Hum. Genet. 104 (1): 99–105.
doi:
10.1007/s004390050917.
PMID10071200.
S2CID19248400.
Yamada K, Sakane F, Imai S, et al. (2003). "Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cells". Biochem. Biophys. Res. Commun. 305 (1): 101–7.
doi:
10.1016/S0006-291X(03)00713-7.
PMID12732202.
Oyaizu K, Kantarci A, Maeda H, et al. (2003). "Identification of mRNAs for the various diacylglycerol kinase isoforms in neutrophils from patients with localized aggressive periodontitis". J. Periodont. Res. 38 (5): 488–95.
doi:
10.1034/j.1600-0765.2003.00680.x.
PMID12941073.
Filosto M, Mancuso M, Tomelleri G, et al. (2004). "Hepato-cerebral syndrome: genetic and pathological studies in an infant with a dGK mutation". Acta Neuropathol. 108 (2): 168–71.
doi:
10.1007/s00401-004-0872-9.
PMID15150663.
S2CID31732164.
Batista EL, Warbington M, Badwey JA, Van Dyke TE (2005). "Differentiation of HL-60 cells to granulocytes involves regulation of select diacylglycerol kinases (DGKs)". J. Cell. Biochem. 94 (4): 774–93.
doi:
10.1002/jcb.20356.
PMID15578578.
S2CID114877.